Consensus-Defined Sarcopenic Obesity and a Related Dynapenic Obesity Phenotype in Relation to Early Cognitive Impairment.

Mu-Cyun Wang, Tao-Chun Peng, Jeng-Min Chiou, Yen-Ching Chen, Jen-Hau Chen

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Article in Journal of cachexia, sarcopenia and muscle, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Mu-Cyun WangDepartment of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan.ORCID https://orcid.org/0000-0001-8011-1007

Tao-Chun PengDivision of Geriatric Medicine, Department of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-1336-288X

Jeng-Min ChiouInstitute of Statistics and Data Science, National Taiwan University, Taipei, Taiwan.ORCID https://orcid.org/0000-0003-4554-9454

Yen-Ching ChenInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.ORCID https://orcid.org/0000-0002-8159-7202

Jen-Hau ChenDepartment of Geriatrics and Gerontology, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan.ORCID https://orcid.org/0000-0002-7141-1582

Funding

Ministry of Science and Technology in Taiwan 100-2314-B-002-103Ministry of Science and Technology in Taiwan 101-2314-B-002-126-MY3Ministry of Science and Technology in Taiwan 103-2314-B-002-033-MY3Ministry of Science and Technology in Taiwan 104-2314-B-002-038-MY3Ministry of Science and Technology in Taiwan 107-2314-B-002-186-MY3Ministry of Science and Technology in Taiwan 107-2314-B-002-230Ministry of Science and Technology in Taiwan 108-2314-B-002-128-MY2Ministry of Science and Technology in Taiwan 110-2314-B-002-068Ministry of Science and Technology in Taiwan 110-2314-B-002-129-MY3Ministry of Science and Technology in Taiwan 111-2314-B-002-090-MY3Ministry of Science and Technology in Taiwan 113-2314-B-002-188-MY3Ministry of Science and Technology in Taiwan 113-2621-M-002-020Ministry of Science and Technology in Taiwan 114-2314-B-002-062-MY3

6 · The paper itself

Abstract

backgroundPrevious studies examining sarcopenic obesity in relation to cognitive function have utilized heterogeneous operational definitions. Some studies have evaluated low muscle strength combined with obesity, more appropriately described as dynapenic obesity, under the broader term sarcopenic obesity. We examined the associations of consensus-defined sarcopenic obesity and a related strength-based obesity phenotype with global and domain-specific cognitive function in older adults and evaluated the robustness of these associations across alternative adiposity definitions.

methodsThis prospective cohort study (2015-2019) included non-demented older adults from the Taiwan Initiative for Geriatric Epidemiological Research. Participants underwent cognitive assessments at baseline and at the 2-year follow-up. Handgrip strength was measured using a dynamometer, and total muscle mass was measured by bioelectrical impedance analysis. Obesity was defined primarily as a body mass index ≥ 27 kg/m

resultsAt baseline, 366 older adults aged ≥ 69 years (54.6% women, mean ± standard deviation [SD] = 75.7 ± 4.8 years) were included. All 16 participants with dynapenic obesity also met the criteria for sarcopenic obesity. Sarcopenic obesity was associated with poor global cognition (MoCA-T:

conclusionsSarcopenic obesity and a related dynapenic obesity phenotype were associated with poor global and domain-specific cognitive function in non-demented older adults. Muscle strength and obesity measures may facilitate early identification of these phenotypes and help identify individuals at increased risk of cognitive impairment. Future studies are needed to determine whether targeted interventions for sarcopenic and dynapenic obesity can prevent or delay cognitive decline.

Indexed as

Cognitive DysfunctionObesitySarcopeniaAgedAged, 80 and overFemaleHand StrengthHumansMaleMuscle StrengthPhenotypeProspective Studiescognitive impairmentdynapenic obesityhandgrip strengthmuscle massobesitysarcopenic obesity

Identifiers

PMID42825653

DOI10.1002/jcsm.70395

PMCPMC13632612

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.