Evidence map›Paper›PMID 42825366›Full record

ArticleInternational journal of molecular medicine2026

Spatial multi‑omics identifies an SPP1+ macrophage‑driven anti‑apoptotic niche in osteoarthritis synovium via the SPP1‑CD44 axis.

Han Gong, Hao Shen, Feng Zhang, Wei Wang, Sheng Zhou, Lei Wang, Yu Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Han Gong *Department of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.
Hao Shen *Department of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.
Feng Zhang *Department of Medical Research Center, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.
Wei WangDepartment of Orthopedics, Yangzhou Clinical College of Xuzhou Medical University, Yangzhou, Jiangsu 225001, P.R. China.
Sheng ZhouState Key Laboratory of Pharmaceutical Biotechnology, Department of Orthopedic Surgery, Division of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, Nanjing University, Nanjing, Jiangsu 210008, P.R. China.
Lei WangDepartment of Medical Research Center, The Yangzhou Clinical College of Xuzhou Medical University, Yangzhou, Jiangsu 225001, P.R. China.
Yu SunDepartment of Orthopedics, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu 225001, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) progression is driven by chronic synovitis. However, the spatially organized macrophage subsets that sustain unresolved inflammation through evasion of apoptosis remain poorly characterized. The present study investigated the functional subsets and spatial niches of synovial macrophages that regulate apoptotic pathways in OA pathogenesis. Spatial transcriptomics, single‑cell RNA sequencing and

Indexed as

ApoptosisHyaluronan ReceptorsMacrophagesOsteoarthritisOsteopontinSynovial MembraneAnimalsHumansMaleMiceMice, Inbred C57BLSignal TransductionSpatial TranscriptomicsHyaluronan ReceptorsOsteopontinapoptosisosteoarthritisSPP1+ macrophagessynovitis

Identifiers

PMID42825366
PMCPMC13637569

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.