Evidence map›Paper›PMID 42825294›Full record

ArticleHorticulture research2026

Integrating genome-wide association study and transcriptomic profiling identifies candidate genes underlying soluble solids content in melon (

Xuxu Niu, Qiong Li, Lei Cao, Yachen Liu, Junhao Qiang, Zhu Lian, Yi Xie, Qing Meng, Wenkai Yan, Panqiao Wang and 10 more

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Article in Horticulture research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

20 authors.

Xuxu NiuCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Qiong LiCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Lei CaoCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Yachen LiuCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Junhao QiangCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Zhu LianCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Yi XieCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Qing MengCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Wenkai YanCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.ORCID https://orcid.org/0009-0007-3181-4022
Panqiao WangCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Xiang LiCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Wenwen MaoCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Juan HouCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Lili LiCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Luming YangCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.ORCID https://orcid.org/0000-0003-2151-023X
Junlong FanKaifeng Academy of Agriculture and Forestry, Kaifeng 475000, China.
Yan GuoKaifeng Academy of Agriculture and Forestry, Kaifeng 475000, China.
Zhiqiang ChengKaifeng Academy of Agriculture and Forestry, Kaifeng 475000, China.
Chen LuoCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.
Jianbin HuCollege of Horticulture, Henan Agricultural University, Zhengzhou 450046, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Soluble solids content (SSC) is a major determinant of flavor quality in melon fruit; however, the key genes regulating this trait remain poorly characterized. To elucidate the molecular basis of SSC variation, we performed genome-wide association studies (GWAS) using a diverse panel of 200 melon accessions, which detected 79 significant single nucleotide polymorphisms associated with SSC. Linkage disequilibrium decay analysis annotated 86 candidate genes within the associated genomic regions. To prioritize functionally relevant candidates, we further integrated transcriptome data from two genotypes with contrasting SSC levels, 'San Ye Hua sugua' (SYH; low SSC) and 'Bai Sha Mi' (BSM; high SSC). Comparative transcriptomic analysis revealed 18 candidate genes that were both GWAS-associated and differentially expressed between the two genotypes. Subsequent qRT-PCR validation confirmed concordant expression patterns for 14 of these candidates. Haplotype analysis demonstrated that natural variation at these loci was significantly correlated with SSC phenotypic variation across the population. Physicochemical component analysis revealed sucrose as the major driver of SSC accumulation. Five key candidate genes (

Identifiers

PMID42825294
PMCPMC13630446

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