Evidence map›Paper›PMID 42825117›Full record

ArticleResuscitation plus2026

Quantification of blood-based neurovascular unit biomarkers: an analytical platform comparison study.

Chloe P Allen, Dorothée J Goulet, Sophie Stukas, Andrew M Agbay, Tessa F Morelli, Tali Romero, Veronica Hirsch-Reinshagen, Cheryl L Wellington, Mypinder S Sekhon, Jordan D Bird

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Resuscitation plus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chloe P AllenDivision of Critical Care Medicine, Department of Medicine, Vancouver General Hospital, West 12th Avenue, University of British Columbia, Vancouver, BC, Canada.
Dorothée J GouletDivision of Critical Care Medicine, Department of Medicine, Vancouver General Hospital, West 12th Avenue, University of British Columbia, Vancouver, BC, Canada.
Sophie StukasDivision of Critical Care Medicine, Department of Medicine, Vancouver General Hospital, West 12th Avenue, University of British Columbia, Vancouver, BC, Canada.
Andrew M AgbayDjavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Tessa F MorelliDjavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Tali RomeroDjavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Veronica Hirsch-ReinshagenDepartment of Pathology and Laboratory Medicine, Vancouver General Hospital, West 12th Avenue, University of British Columbia, Vancouver, BC, Canada.
Cheryl L WellingtonDjavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.
Mypinder S SekhonDivision of Critical Care Medicine, Department of Medicine, Vancouver General Hospital, West 12th Avenue, University of British Columbia, Vancouver, BC, Canada.
Jordan D BirdDivision of Critical Care Medicine, Department of Medicine, Vancouver General Hospital, West 12th Avenue, University of British Columbia, Vancouver, BC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hypoxic ischemic brain injury (HIBI) remains a significant cause of morbidity and mortality in patients following cardiac arrest. Many international guidelines for HIBI prognostication advocate for a multimodal approach with inclusion of blood-based biomarkers. However, advancements in analytical technology have increased uncertainty in selecting the optimal quantification tool and impeded application of these results across platforms in accordance with amalgamated prognostication thresholds. Methods: We conducted a Results: GFAP, Nf-L, Tau, and UCH-L1 were highly correlated between the Conclusion: Collectively, this cross-platform validation highlights the importance of device-specific analytical methods and prognostication thresholds for each analytical platform considered for use in clinical practice.

Indexed as

Blood-based neurologic biomarkersGFAPHypoxic ischemic brain injuryNeurofilament light-chainPost-cardiac arrest brain injuryUCH-L1

Identifiers

PMID42825117
PMCPMC13629343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.