Evidence map›Paper›PMID 42825106›Full record

ArticleNature reviews. Methods primers2026

Towards credible digital twins for basic and preclinical research.

Colleen E Clancy, Bennett A Landman

Abstract read
In one paragraph

Article in Nature reviews. Methods primers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Colleen E ClancyCenter for Precision Medicine and Data Sciences, University of California, Davis, Davis, CA, USA.
Bennett A LandmanDepartment of Electrical and Computer Engineering, Vanderbilt University, Nashville, TN, USA.

Funding

Digital Twins from the Atom to the RhythmR01HL174001 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI COLLEEN E CLANCY, Luis F Santana · 2024 to 2026
$2.4M
NHLBI NIH HHS R01 HL174001
6 · The paper itself

Abstract

Digital twins are well established in industrial settings, but there has not been wide adoption in biomedical settings. Digital twins for biomedical applications are now possible with the inclusion of artificial intelligence and the potential to combine mechanistic and clinical models that learn and adjust for human variability.

Identifiers

PMID42825106
PMCPMC13629308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.