Evidence map›Paper›PMID 42825098›Full record

ArticleNational science review2026

Integrative analysis of the embryonic origin of adult neural stem cells in forebrain subventricular zones.

Huan Wu, Ke Tang, Ruimin Xu, Tao Li, Keke Liang, Xuanxuan Wang, Deyuan Huang, Yijia Yang, Yanxuan Yin, Jiayang Xie and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in National science review, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Huan WuShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.
Ke TangKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.
Ruimin XuShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.
Tao LiDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Keke LiangDepartment of Neurology, Shanghai Tongji Hospital, School of Medicine, Tongji University, Shanghai 200092, China.
Xuanxuan WangShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.
Deyuan HuangShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.
Yijia YangShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.
Yanxuan YinShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.
Jiayang XieShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.
Chong LiShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.
Xiaoyu LiuShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.ORCID https://orcid.org/0000-0001-6622-9316
Qing-Ran BaiKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.
Chenfei WangKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.ORCID https://orcid.org/0000-0001-7573-3768
Qin ShenKey Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.ORCID https://orcid.org/0000-0002-9000-494X
Shaorong GaoShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University; Frontier Science Center for Stem Cell Research, Tongji University, Shanghai 200092, China.ORCID https://orcid.org/0000-0003-1041-3928

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the mammalian brain, adult neural stem cells (NSCs) located in the ventricular-subventricular zone (V-SVZ) of lateral ventricles and dentate gyrus continuously generate new neurons and glia throughout life. The adult NSCs in V-SVZ are derived from ventricular radial glial cells (RGCs) which become quiescent during embryonic development. However, the origin and establishment of this adult NSC pool remain elusive, primarily due to the challenge of tracing the lineage from embryonic RGCs to their quiescent adult successors. Here, by leveraging Vcam1-a marker continuously expressed from embryonic RGCs to adult NSCs, we unravel the dynamic process and regulatory mechanism underlying the fate bifurcation that gives rise to quiescent seed cells. We demonstrate that Vcam1

Indexed as

adult NSCsembryonic originlineage tracingquiescencescMulti-omicsVcam1

Identifiers

PMID42825098
PMCPMC13629234

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.