ArticleACS omega2026
Combination of Polymeric Microneedles with Specific Peptide for TNF‑α Sensing Via Noninvasive Detection in Interstitial Fluid.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Microneedle (MN)-based biosensors offer a minimally invasive and blood-free approach for real-time monitoring of clinically relevant biomarkers in interstitial fluid (ISF). Pro-inflammatory cytokines such as Tumor Necrosis Factor-α (TNF-α) can reach higher concentrations in ISF than in serum, which makes this fluid particularly sensitive for detecting early local inflammatory responses. Here, we introduce an antibody-free MN biosensor employing a synthetic high-affinity peptide (P52) for TNF-α recognition in ISF. The novelty of the platform lies in the stable immobilization of the P52 peptide directly on mechanically robust polymeric MNs for a scalable three-dimensional fluorescence assay. The results reported show how the limitations commonly associated with translating monoclonal antibody-based molecular recognition could be overcome using a functionalized polymeric microneedle platform. Poly-(lactic-
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