ArticleVeterinary and animal science2026
Nonlinear dose-response evaluation of RenalMax supplementation in broiler chickens.
Article in Veterinary and animal science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study evaluated the effects of RenalMax, a phytogenic blend containing nettle extract, sorbitol, ammonium chloride, and vitamins (B1, B2, B6, and C), on growth performance, serum biochemical variables, antioxidant status, and mineral metabolism in broiler chickens. A total of 400 one-day-old male Ross 308 broilers were randomly assigned to four treatments receiving 0, 0.25, 0.50, or 1.00 mL RenalMax/L drinking water, with five replicate pens of 20 birds per treatment, and were reared for 42 d RenalMax supplementation increased body weight gain and feed intake (P < 0.05), with the greatest response observed at 0.50 mL/L. Serum uric acid, creatinine, and blood urea nitrogen concentrations decreased (P < 0.001), whereas albumin and total protein concentrations increased. Supplementation was also associated with lower serum triglyceride, total cholesterol, low-density lipoprotein, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and malondialdehyde concentrations, together with higher high-density lipoprotein, total antioxidant capacity, glutathione peroxidase activity, and serum calcium and phosphorus concentrations (P < 0.05). Principal component analysis distinguished treatment groups based on the combined variation of growth performance, serum biochemical, antioxidant, and mineral variables. Dose-response analyses using polynomial and segmented regression models identified nonlinear responses for several variables, with model-estimated optima generally occurring between 0.5 and 0.6 mL/L within the evaluated supplementation range. Overall, RenalMax supplementation was associated with favorable changes in growth performance and multiple serum biochemical, antioxidant, and mineral-related variables in broiler chickens, although the estimated optimal supplementation level should be confirmed under commercial production conditions.
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