ReviewCell insight2026
Beyond immune suppression: regenerative programs in regulatory T cells.
Review in Cell insight, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulatory T cells (Tregs) are traditionally recognized for their indispensable roles in maintaining immune tolerance and suppressing excessive inflammation. However, accumulating evidence has revealed an unexpected regenerative dimension of Treg biology across multiple tissues. Here, regenerative function refers to the capacity of Tregs to directly regulate stem cells, stromal cells, epithelial cells, and other non-immune tissue cells through specialized reparative mediators, thereby contributing to restoration of tissue structure, cellular composition, or function. Emerging studies demonstrate that these regenerative activities are triggered by tissue injury and coordinated by diverse reparative signals. Notably, in selected experimental settings, specific tissue-regenerative pathways can be mechanistically distinguished from canonical immune-regulatory functions of Tregs, although these programs frequently operate in a coordinated and complementary manner during physiological tissue restoration. In this review, we summarize tissue-adapted regenerative programs employed by Tregs across diverse organs, discuss common principles underlying regenerative Treg biology, and evaluate evidence for dedicated regenerative Treg states. Finally, we propose a conceptual framework in which Tregs function as dual-purpose regulators of both immune homeostasis and tissue restoration, highlighting their broader significance in physiology, disease, and regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.