Evidence map›Paper›PMID 42824987›Full record

ArticleClinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology2026

A case of congenital hyperinsulinism with

Ikumi Umeki, Tomohiro Nakagawa, Akinobu Miura, Sayaka Kawashima, Hirohito Shima, Chisumi Sogi, Dai Suzuki, Masaki Ito, Naohisa Ishibashi, Shigeo Suzuki and 4 more

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In one paragraph

Article in Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ikumi UmekiDepartment of Pediatrics, Tohoku University Hospital, Sendai, Japan.
Tomohiro NakagawaDepartment of Pediatrics, Tohoku University Hospital, Sendai, Japan.
Akinobu MiuraDepartment of Pediatrics, Tohoku University Hospital, Sendai, Japan.
Sayaka KawashimaDepartment of Pediatrics, Tohoku University Hospital, Sendai, Japan.
Hirohito ShimaDepartment of Pediatrics, Tohoku University Hospital, Sendai, Japan.
Chisumi SogiDepartment of Pediatrics, Tohoku University Hospital, Sendai, Japan.
Dai SuzukiDepartment of Pediatrics, Tohoku University Hospital, Sendai, Japan.
Masaki ItoDepartment of Pediatrics, Soma General Hospital, Soma, Japan.
Naohisa IshibashiDepartment of Pediatrics, Ohara General Hospital, Fukushima, Japan.
Shigeo SuzukiDepartment of Pediatrics, Ohara General Hospital, Fukushima, Japan.
Toru TakahashiDepartment of Genetics Medicine, Osaka City General Hospital, Osaka, Japan.
Tohru Yorifuji2nd Department of Internal Medicine, Date Red Cross Hospital, Date, Japan.
Atsuo KikuchiDepartment of Pediatrics, Tohoku University Hospital, Sendai, Japan.
Junko KannoDepartment of Pediatrics, Tohoku University Hospital, Sendai, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital hyperinsulinism (CHI) is a rare disorder resulting in hypoglycemia due to increased insulin secretion and is subdivided into focal and diffuse forms. CHI is associated with neurological damage due to hypoglycemia, making adequate blood glucose management crucial. Although subcutaneous octreotide injection can effectively treat CHI, frequent octreotide administration may be burdensome for patients and their families. Here, we describe a boy with early neonatal-onset persistent CHI treated with octreotide long-acting release (LAR). At first, he received treatment with continuous glucose infusion, diazoxide, and glucagon. Genetic analysis revealed the patient was a compound heterozygote for

Indexed as

ABCC8congenital hyperinsulinismoctreotide LAR

Identifiers

PMID42824987
PMCPMC13630435

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.