Evidence map›Paper›PMID 42824949›Full record

ReviewClinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology2026

Idiopathic short stature in the genomic era: a focused narrative review of genotype-phenotype correlation, selective neuroimaging, IGF-1 biology, and growth hormone responsiveness.

Ashraf Soliman, Fawzia Alyafei, Ahmed Elawwa, Nada Alaaraj, Noor Hamed, Shayma Mohamed

Abstract readReview
In one paragraph

Review in Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ashraf SolimanDepartment of Pediatrics, Hamad Medical Corporation, Doha, Qatar.
Fawzia AlyafeiDepartment of Pediatrics, Hamad Medical Corporation, Doha, Qatar.
Ahmed ElawwaDepartment of Pediatrics, Hamad Medical Corporation, Doha, Qatar.
Nada AlaarajDepartment of Pediatrics, Hamad Medical Corporation, Doha, Qatar.
Noor HamedDepartment of Pediatrics, Hamad Medical Corporation, Doha, Qatar.
Shayma MohamedDepartment of Pediatrics, Hamad Medical Corporation, Doha, Qatar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic short stature (ISS) is a provisional clinical label rather than a final diagnosis. This narrative review (2000-2026) synthesizes how genomic findings intersect with neuroimaging, IGF-1 biology, and GH responsiveness. Diagnostic yield varies by modality: candidate-gene (4.7%), chromosomal microarray (16.3%), multigene panels (21.6%), and exome sequencing (33.3% overall; 15.1% isolated). These estimates decrease if variants of uncertain significance (VUS) are excluded. Recurrent genes include

Indexed as

genomicsGH responsegrowth plate disordersidiopathic short statureIGF-1pituitary MRI

Identifiers

PMID42824949
PMCPMC13630432

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.