Evidence map›Paper›PMID 42824863›Full record

ArticleTransactions on machine learning research2026

SensX: Model-Agnostic Local Feature Attribution via Calibrated Global Sensitivity Analysis.

Manu Aggarwal, Nick Cogan, Vipul Periwal

Abstract read
In one paragraph

Article in Transactions on machine learning research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

3 authors.

Manu AggarwalLaboratory of Biological Modeling, NIDDK, National Institutes of Health, Bethesda, MD, USA.
Nick CoganDepartment of Mathematics, Florida State University, Tallahassee, FL, USA.
Vipul PeriwalLaboratory of Biological Modeling, NIDDK, National Institutes of Health, Bethesda, MD, USA.

Funding

Intramural NIH HHS Z99 DK999999
6 · The paper itself

Abstract

Local feature attribution is a standard tool for auditing and debugging deep learning predictions, but existing attribution methods are not designed for systems that chain pretrained, frozen, or API-only modules. Gradient-based methods such as Integrated Gradients require an end-to-end computational graph that may be unavailable. Perturbation-based methods such as KernelSHAP require a reference input or background distribution whose choice can substantially alter attributions and may not be defensible for composite pipelines. We present SensX, a local attribution method that treats the model as a black box and replaces arbitrary design choices with interpretable, application-grounded parameters. SensX adapts Morris-style coordinate walks from global sensitivity analysis to local attribution. It requires no access to model internals, training data, or arbitrary reference inputs. We validate SensX across four case studies, each targeting a distinct limitation of existing methods. On a synthetic benchmark where ground-truth relevant features vary per input, SensX reaches 95% top-2 attribution accuracy versus 58% for the best KernelSHAP/Integrated Gradients variant. On a ViT with > 150,000 pixel-channel features, SensX produces spatially coherent maps and exposes systematic intra-patch bias where KernelSHAP is infeasible and Integrated Gradients yields task-irrelevant attributions. On single-cell classifiers with unstructured gene-expression features, SensX attains the lowest top-

Identifiers

PMID42824863
PMCPMC13629644

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.