ArticlemLife2026
z-VAD-FMK triggers macrophage necroptosis during mycobacterial infection via a non-canonical off-target mechanism.
Rong Hu, Pei Li, Jie Han, Jiamin Huang, Guoyi Huang, Xiuju Jiang, Daniel Pfau, Guobao Li, Yi-Nan Gong, Carl F Nathan and 1 more
Abstract read
In one paragraphArticle in mLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Rong HuDepartment of Immunology and Microbiology, School of Life Sciences Southern University of Science and Technology Shenzhen China.
Pei LiDepartment of Immunology and Microbiology, School of Life Sciences Southern University of Science and Technology Shenzhen China.
Jie HanDepartment of Immunology and Microbiology, School of Life Sciences Southern University of Science and Technology Shenzhen China.
Jiamin HuangShenzhen Third People's Hospital The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen China.
Guoyi HuangShenzhen Third People's Hospital The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen China.
Xiuju JiangDepartment of Microbiology and Immunology Weill Cornell Medicine New York New York USA.
Daniel PfauDepartment of Microbiology and Immunology Weill Cornell Medicine New York New York USA.
Guobao LiShenzhen Third People's Hospital The Second Affiliated Hospital of Southern University of Science and Technology Shenzhen China.
Yi-Nan GongDepartment of Immunology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA.
Carl F NathanDepartment of Microbiology and Immunology Weill Cornell Medicine New York New York USA.
Funding
VECTOR CORE FACILITYP30CA047904 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHRISTOPHER J. BAKKENIST · 1988 to 2026
$158.0MHost-directed therapy of tuberculosis: Rescuing macrophages and enhancing their activationR01AI138940 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI NATHAN, CARL FRANCIS · 2018 to 2022
$3.5MNecrotic survivors and plasma membrane integrity signalingDP2GM146320 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI GONG, YI-NAN · 2021 to 2024
$2.3MNCI NIH HHS P30 CA047904NIAID NIH HHS R01 AI138940NIGMS NIH HHS DP2 GM146320
6 · The paper itselfAbstract
Macrophages are the predominant cell type infected by
Indexed as
macrophagemycobacteriaMycobacterium tuberculosisnecroptosisRhodococcus equi
Identifiers
PMID42824841
PMCPMC13628176
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