Evidence map›Paper›PMID 42824833›Full record

ReviewFrontiers in veterinary science2026

Buffering properties of fish aquafeeds: concepts, determinants and effects on physiology and growth.

Lorenzo Márquez, Adrián J Hernández, Rosendo L Azcuy, Nancy E Ruiz, Paola Orellana, Majorie Larson, Gabriel A Morales, Manuel Díaz, Francisco J Moyano, Eduardo Almansa

Abstract readReview
In one paragraph

Review in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lorenzo MárquezCentro de Investigación, Innovación y Creación, Vicerrectoría de Investigación y Posgrado, Universidad Católica de Temuco, Temuco, Chile.
Adrián J HernándezLaboratorio de Nutrición y Fisiología de Peces, Depto. de Ciencias Agropecuarias y Acuícolas, Facultad de Recursos Naturales, Universidad Católica de Temuco, Temuco, Chile.
Rosendo L AzcuyUniversidad de Buenos Aires, Facultad de Agronomía, Departamento de Producción Animal, Buenos Aires, Argentina.
Nancy E RuizEscuela de Medicina Veterinaria, Facultad de Recursos Naturales y Medicina Veterinaria, Universidad Santo Tomás, Temuco, Chile.
Paola OrellanaLaboratorio de Nutrición y Fisiología de Peces, Depto. de Ciencias Agropecuarias y Acuícolas, Facultad de Recursos Naturales, Universidad Católica de Temuco, Temuco, Chile.
Majorie LarsonLaboratorio de Nutrición y Fisiología de Peces, Depto. de Ciencias Agropecuarias y Acuícolas, Facultad de Recursos Naturales, Universidad Católica de Temuco, Temuco, Chile.
Gabriel A MoralesUniversidad de Buenos Aires, Facultad de Agronomía, Departamento de Producción Animal, Buenos Aires, Argentina.
Manuel DíazDepartamento de Biología y Geología, Facultad de Ciencias Experimentales, Universidad de Almería, Almería, Spain.
Francisco J MoyanoDepartamento de Biología y Geología, Facultad de Ciencias Experimentales, Universidad de Almería, Almería, Spain.
Eduardo AlmansaCentro Oceanográfico de Canarias, Instituto Español de Oceanografía, (COC-IEO), CSIC, Santa Cruz de Tenerife, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present paper is a comprehensive review of the existing literature on aquafeed acid binding capacity (ABC), and its effects on the digestive physiology, metabolism, intestinal microbiota, and growth of farmed fishes. ABC can be defined as the quantity of acid (usually HCl) required to reduce diet pH to a specified endpoint, typically 3.0 (ABC-3) or 4.0 (ABC-4). The ABC of a diet may influence the secretion pattern and minimum gastric pH, as well as the total amount of HCl secreted during digestion. On the other hand, the acidity of the gastric lumen plays a crucial role in the digestive processes of many cultured fish species, facilitating the activation of gastric proteases, the initial hydrolysis of dietary proteins, and the solubilization of mineral nutrients. As the secretion of gastric HCl entails energy expenditure, it is plausible that the fraction of the specific dynamic action (SDA, defined as the energetic costs due to food digestion and assimilation), associated with gastric digestion in fish could be modulated through dietary formulations and their corresponding ABC. In fish, available information suggests that a decrease in diet ABC can lead to a reduction in total specific dynamic action (SDA), while the effects on growth rates remain ambiguous or transitory. Modifications to diet ABC through supplementation with calcium carbonate (CaCO₃) may negatively impact growth rates due to a concomitant decrease in phosphorus digestibility rather than an increase in HCl secretion. Furthermore, when the costs of HCl secretion were examined using proton-pump inhibitors, such as omeprazole, both SDA values and durations decreased similarly, being this reduction directly correlated with diminished fish growth rates. Regarding the influence of dietary buffering properties on fish gut microbiota, from the few available studies it can be deduced that the effects are not very significative, but this could be just a consequence of the immaturity of the research on diet ABC and fish microbiota. Further research is warranted to determine whether the manipulation of dietary ABC can lead to enhanced growth rates and improved intestinal health in cultured fish.

Indexed as

acid binding capacityaquafeedsdigestive physiologyfish growthintestinal microbiotaspecific dynamic action

Identifiers

PMID42824833
PMCPMC13629529

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.