ArticleFrontiers in veterinary science2026
Deciphering cysteamine's impact on cashmere-producing traits of cashmere goats: a transcriptomic and metabolomic perspective.
Article in Frontiers in veterinary science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: This study addresses the practical production problem of inferior cashmere quality in cashmere goats. We supplemented cysteamine (CS) in diets to regulate cashmere‑production‑related traits and explore its underlying nutritional regulatory pathways, so as to support the scientific and rational application of cysteamine in cashmere goat production. Methods: Sixty healthy 18‑month‑old female Inner Mongolia cashmere goats were selected for this single‑factor randomized trial and randomly allocated into three groups ( Results: Dietary CS numerically improved cashmere yield, weight and scale height without statistical significance. The LCS treatment significantly increased straightened length, while staple length slightly decreased in the HCS group but remained higher than in CON. Initial cashmere diameter, strength and elongation at break showed no inter‑group differences; these three indicators increased after CS supplementation compared with baseline values. In total, 426 DEGs and 72 DEMs were detected, indicating obvious transcriptional and metabolic changes induced by CS. KEGG analysis highlighted divergence in the cAMP signaling pathway and thyroid hormone synthesis. DEMs were mainly enriched in lipid metabolism, organic acid metabolism and heterocyclic compound metabolism; L‑cysteine‑glutathione disulfide and α‑lipoic acid were key sulfur‑containing differential metabolites. Multi‑omics integration confirmed differences in lipid metabolism and cyclic nucleotide signaling pathways, with lipid‑related genes ( Discussion: Multi‑omics results indicate that cysteamine may improve cashmere‑goat productive traits by providing endogenous organic sulfur sources, accumulating sulfur‑containing metabolic intermediates and coordinating hair‑follicle‑development‑related signaling pathways. This work supplies experimental evidence for cashmere fiber quality improvement.
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