ReviewEJHaem2026
Ovarian Reserve in Women of Reproductive Age With Sickle Cell Anaemia: A Scoping Review.
Review in EJHaem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sickle cell anaemia (SCA) is an inherited haemoglobinopathy disproportionately common among people of African origin, though it affects multiple global populations. Emerging evidence suggests that chronic haemolysis, inflammation and treatment exposures in SCA may affect ovarian function. This scoping review aimed to map available evidence on ovarian reserve in women of reproductive age with SCA. Methods: PubMed/MEDLINE, Embase, Scopus, Web of Science and CINAHL were searched from inception to 31 January 2026, using Boolean operators combining terms related to SCA, ovarian reserve, anti-Müllerian hormone (AMH), antral follicle count (AFC) and follicle-stimulating hormone (FSH). Studies reporting biochemical or radiographic ovarian reserve in reproductive-aged women with SCA were included. Due to heterogeneous methodologies, data were extracted via standardised forms and narratively synthesised. Results: Seven studies met the inclusion criteria, comprising six observational studies and one retrospective multi-centre fertility preservation cohort (total Conclusion: The available evidence indicates that women of reproductive age with SCA, particularly those with HbSS genotype, may demonstrate lower ovarian reserve indices compared to age-matched HbAA controls, though the cross-sectional nature of most studies limits causal inference. These findings highlight the need for early reproductive counselling and further longitudinal research. Trial Registration: The authors have confirmed clinical trial registration is not needed for this submission.
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Registered trials
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