Evidence map›Paper›PMID 42824708›Full record

ArticleBrain, behavior, & immunity - health2026

Fast and slow gene expression changes in blood following acute social stress.

Hampus Grönvall, Sylvia Abdelhalim, Fara Tabrizi, Sini Ezer, Gamze Yazgeldi Gunaydin, Erik Arner, Jörgen Rosén, Shintaro Katayama, Juha Kere, Fredrik Åhs and 1 more

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Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hampus GrönvallDepartment of Education, Psychology and Social Work, Mid Sweden University, Östersund, Sweden.
Sylvia AbdelhalimDepartment of Education, Psychology and Social Work, Mid Sweden University, Östersund, Sweden.
Fara TabriziDepartment of Education, Psychology and Social Work, Mid Sweden University, Östersund, Sweden.
Sini EzerFolkhälsan Research Centre, Helsinki, Finland.
Gamze Yazgeldi GunaydinFolkhälsan Research Centre, Helsinki, Finland.
Erik ArnerRIKEN, Yokohama, Japan.
Jörgen RosénDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Shintaro KatayamaFolkhälsan Research Centre, Helsinki, Finland.
Juha KereFolkhälsan Research Centre, Helsinki, Finland.
Fredrik ÅhsDepartment of Education, Psychology and Social Work, Mid Sweden University, Östersund, Sweden.
Lea MikkolaTurku Bioscience Centre, University of Turku, Turku, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Social stress is a risk factor for psychiatric disorders and also influences immune function. While it is known that acute social stress impacts the number of immune cells in circulation, the temporal dynamics of stress induced immune-related transcriptional changes in human blood remain unclear. To investigate changes in gene expression, we exposed 27 adults to the Trier Social Stress Test (TSST), and collected blood at baseline, as well as 5, 30, 60 and 90 min after stress. Whole-blood gene expression was profiled using a 5' targeted RNA-sequencing method (STRT). Differential expression was analyzed using linear and cubic models. We observed a total of 54 differentially expressed genes following stress. Fast responses, with a transient peak immediately following stress, were enriched for cytotoxic T-cell, NK-cell and dendritic cell functions (e.g.,

Identifiers

PMID42824708
PMCPMC13627809

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.