Evidence map›Paper›PMID 42824688›Full record

ArticleClinical kidney journal2026

Novel associations of Claudin gene variants with kidney stone disease.

Iris Y Liu, Jenna Haverfield, Elby MacKenzie, Line Dufresne, Aimee K Ryan, James C Engert, Indra R Gupta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Iris Y LiuDepartment of Human Genetics, McGill University, Montréal, QC, Canada.ORCID https://orcid.org/0009-0006-9444-6602
Jenna HaverfieldResearch Institute of the McGill University Health Centre, Montréal, QC, Canada.ORCID https://orcid.org/0000-0002-4893-7797
Elby MacKenzieDepartment of Human Genetics, McGill University, Montréal, QC, Canada.ORCID https://orcid.org/0009-0005-8373-4767
Line DufresneResearch Institute of the McGill University Health Centre, Montréal, QC, Canada.ORCID https://orcid.org/0000-0001-6923-8517
Aimee K RyanDepartment of Human Genetics, McGill University, Montréal, QC, Canada.ORCID https://orcid.org/0000-0002-1601-1324
James C EngertDepartment of Human Genetics, McGill University, Montréal, QC, Canada.ORCID https://orcid.org/0000-0001-8411-4790
Indra R GuptaDepartment of Human Genetics, McGill University, Montréal, QC, Canada.ORCID https://orcid.org/0000-0002-2460-746X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The tight junction family of claudin proteins regulates paracellular ion transport in the nephron and across epithelial and endothelial barriers throughout the body. Rare recessive variants in Methods: We analyzed 415 237 UK Biobank participants (9009 kidney stone cases and 406 228 controls) using exome sequencing and imputed genotype data spanning all 24 human Results: Forty-three novel coding variant associations were identified through exome sequencing, including two Conclusions: Beyond established FHHNC genes, multiple

Indexed as

calcium homeostasisclaudinsexome sequencingfamilial hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC)genetic associationUK Biobank

Identifiers

PMID42824688
PMCPMC13627830

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.