Evidence map›Paper›PMID 42824654›Full record

ArticleClinical parkinsonism & related disorders2026

Impact of type 2 diabetes mellitus on acute levodopa responsiveness in Parkinson's disease: A Multicenter retrospective study.

Olga Stockmann, Lan Ye, Carsten Buhmann, Fabian Maass, Christoph van Riesen, Christiane Weinrich, Florian Wegner, Matthias Höllerhage, Monika Pötter-Nerger, Martin Klietz

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Article in Clinical parkinsonism & related disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Olga StockmannDepartment of Neurology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Lan YeDepartment of Neurology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Carsten BuhmannDepartment of Neurology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Fabian MaassDepartment of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Christoph van RiesenDepartment of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Christiane WeinrichDepartment of Neurology, University Medical Center Göttingen, 37075 Göttingen, Germany.
Florian WegnerDepartment of Neurology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Matthias HöllerhageDepartment of Neurology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.
Monika Pötter-NergerDepartment of Neurology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Martin KlietzDepartment of Neurology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a common comorbidity in Parkinson's disease (PD) and may influence the progression and dopaminergic function, suggesting a potential impact on levodopa responsiveness. Objective: To examine the impact of T2DM status on levodopa responsiveness in an acute levodopa challenge in PD. Methods: We retrospectively analyzed the total and subdomain motor responses in the acute levodopa challenge in 136 PD patients with normal glycemic status, prediabetes, or T2DM across three German centers. Results: Levodopa responsiveness did not differ significantly among the three glycemic groups. The only between-group difference was more severe rest tremor in T2DM patients in the OFF state, which was no longer present in the ON state due to greater levodopa-induced improvement. Conclusion: An acute levodopa challenge remained similarly effective across glycemic groups in PD, suggesting that T2DM does not substantially modify acute dopaminergic treatment response. Future studies should also evaluate chronic response to levodopa across different glycemic statuses.

Indexed as

Levodopa challengeMotor responseParkinson's diseaseType 2 diabetes mellitus

Identifiers

PMID42824654
PMCPMC13627794

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.