ArticlePulmonary circulation2026
Pulmonary Arterial Hypertension Associated With Chronic Mephedrone Use: A Case Report.
Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mephedrone is a synthetic cathinone with sympathomimetic effects, but has not previously been linked to pulmonary arterial hypertension (PAH). We report a 42-year-old woman with no prior cardiopulmonary disease who presented with severe pre-capillary PAH after a decade of near-daily mephedrone use. Extensive evaluation-including autoimmune, infectious, genetic, and imaging studies-excluded recognised causes of PAH. Following cessation of mephedrone and initiation of dual oral PAH-targeted therapy, she demonstrated substantial initial clinical and haemodynamic improvement; however, the response remained incomplete, necessitating further treatment escalation with selexipag. This appears to be the first reported case of PAH linked to mephedrone use.
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Registered trials
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