ArticleIndian journal of orthopaedics2026
Denosumab Injection Combined with Intramedullary Nail Fixation for Osteoporotic Fractures.
Article in Indian journal of orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the clinical efficacy of denosumab injection combined with intramedullary nail fixation for osteoporotic femoral intertrochanteric fractures. Methods: A total of 106 patients diagnosed with osteoporotic femoral intertrochanteric fractures, classified according to the Evans-Jensen system, who were admitted to The First Affiliated Hospital of Guangzhou University of Chinese Medicine between May 2019 and May 2024. All patients underwent internal fixation using the proximal femoral nail antirotation (PFNA) system. The study group received denosumab injections within 1 week postoperatively, and both groups were administered conventional osteoporosis treatment following surgery. The baseline data (age, sex, cause of injury, and Evans-Jensen classification), operation time, intraoperative blood loss, length of hospital stay, fracture healing time, Results: All 106 patients were followed up for at least 1 year. There was no significant difference in operation time, intraoperative blood loss, hospital stays, fracture healing time, and HHS between the two groups ( Conclusion: In summary, the integrative therapeutic protocol combining denosumab administration with proximal femoral nail antirotation (PFNA) fixation demonstrates marked efficacy in enhancing femoral neck bone mineral density and reducing fracture-related limb pain among elderly patients with osteoporotic intertrochanteric fractures. This evidence-based dual-intervention strategy not only optimizes fracture healing outcomes, but also represents a valuable clinical approach for comprehensive postoperative rehabilitation in this vulnerable patient population.
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