ReviewFrontiers in cell and developmental biology2026
Mechanoresponsive reprogramming of tumor-associated macrophages during cancer progression.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Tumor-associated macrophages (TAMs) are critical regulators of the tumor microenvironment. They exhibit diverse pro-tumorigenic and antitumor phenotypes depending on their monocyte-derived or tissue-resident origins. Beyond biochemical signaling, the mechanical properties of the tumor microenvironment, including extracellular matrix stiffness, density, architecture, and spatial heterogeneity, can regulate TAM behavior. This review discusses how these mechanical cues influence TAM infiltration, polarization, and tumor-supportive functions. We further highlight how spatially distinct mechanical environments contribute to TAM heterogeneity within solid tumors. Furthermore, we evaluate how advanced 3D biomimetic cancer platforms, including hydrogels, spheroids, organoids, and microfluidic organ-on-a-chip models, have become essential for accurately recapitulating these mechanoresponsive behaviors and phenotypic adaptations
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