ReviewFrontiers in chemistry2026
Next-generation nanomedicine for cancer therapy: advances, challenges, and future perspectives.
Review in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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Abstract
In recent times, permeation of nanotechnology to modern medicine has revolutionized transformation, especially in the case of cancer diagnosis and therapy, positioning nanomedicine as a key pillar of next-generation healthcare. Tuning the physicochemical properties of nanoparticles such as size, morphology, and surface charge, enables controlled targeted drug delivery, increased cellular uptake and controlled therapeutic release. Nanomedicine-based platforms can improve certain drawbacks associated with conventional therapies including poor aqueous solubility, unfavorable pharmacokinetics, systemic toxicity and low bioavailability for specific therapeutic agents. While consistent tumor-specific accumulation, intratumoral heterogeneity, drug resistance, and long-term therapeutic outcomes remains challenging and highly formulation- and patient-dependent. This review paper besides, focussing on individual nanocarrier classes or specific therapeutic modalities, also provide an integrated and critical perspective on next-generation nanomedicine by connecting nanocarrier design with tumor-specific accumulation, intracellular trafficking, stimuli-responsive drug release, combination therapy and clinical translation. Recent advances in polymeric, lipid-based, inorganic, biological, and hybrid nanocarriers are systematically discussed, with particular stress on surface engineering, ligand-mediated targeting, multifunctional delivery systems and nanoengineered cancer medicine. The potential of these platforms for elevating therapeutic precision, overcoming biological barriers, multidrug resistance and enabling site-specific delivery is critically studied. In addition, major translational challenges, including large-scale fabrication, reproducibility, long-term safety, regulatory barriers, and nanotoxicological concerns are also addressed. Finally, emerging directions involving personalized nanomedicine, combination therapies, and artificial intelligence-assisted nanoparticle design are highlighted to provide perspectives toward safer, more effective, and patient-concentrated cancer therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.