ArticleFrontiers in neuroanatomy2026
Heparan sulfate endosulfatases, Sulf1 and Sulf2, are required for formation of the medial habenula-interpeduncular nucleus circuit.
Article in Frontiers in neuroanatomy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The medial habenula (MHb), a medial subdivision of the habenula located in the dorsal diencephalon, sends axons towards the interpeduncular nucleus (IPN) through the fasciculus retroflexus. Upon reaching the IPN, MHb axons cross the midline multiple times. Although heparan sulfate proteoglycans have previously been shown to play a role in MHb axon guidance, the role of heparan sulfate 6-O-endosulfatases, Sulfatase 1 (Sulf1) and Sulfatase 2 (Sulf2), has to date not been investigated. We thus examined MHb axon trajectories in
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