Evidence map›Paper›PMID 42824324›Full record

ArticleFrontiers in systems neuroscience2026

Are you afraid? Neurophysiological responses to multidimensional fear in an interactive semi-immersive environment.

Milton O Candela, J Emiliano Calderón-Gurubel, Alexandro A Ortiz-Espinoza, Josemaria Elizondo-Garcia, Carol S Vélez-Saboyá, Jorge De-J Lozoya-Santos, Ignacio Rodriguez-Sanchez, Manuel Cebral-Loureda, Mauricio A Ramírez-Moreno

Abstract read
In one paragraph

Article in Frontiers in systems neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Milton O CandelaTecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Mexico.
J Emiliano Calderón-GurubelTecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Mexico.
Alexandro A Ortiz-EspinozaTecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Mexico.
Josemaria Elizondo-GarciaTecnologico de Monterrey, School of Humanities and Education, Monterrey, Mexico.
Carol S Vélez-SaboyáTecnologico de Monterrey, School of Humanities and Education, Monterrey, Mexico.
Jorge De-J Lozoya-SantosTecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Mexico.
Ignacio Rodriguez-SanchezUniversidad Autonoma de Queretaro, Facultad de Lenguas y Letras, Santiago de Querétaro, Mexico.
Manuel Cebral-LouredaTecnologico de Monterrey, School of Humanities and Education, Monterrey, Mexico.
Mauricio A Ramírez-MorenoTecnologico de Monterrey, School of Engineering and Sciences, Monterrey, Mexico.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Objective fear recognition is crucial for clinical evaluation and understanding emotional processing. This study uses a multi-modal biophysical approach (EEG, HRV, EDA) within an interactive, semi-immersive environment to investigate coordinated brain-body responses across multidimensional fear scenarios. Methods: Ten participants experienced four fear-related scenes mapped to Kantian cognitive dimensions (Embodied, Conceptual, Discursive, Integrative) featuring real-time adaptive audiovisuals. EEG, HRV, and EDA metrics were concurrently recorded and normalized to a resting baseline to evaluate shared signatures, scene-specific modulations, and cross-modal correlations. Results: Neural and autonomic fear markers included frontal and parietal activation, elevated EEG-derived indices (Fatigue, Excitement, Engagement), and increased heart rate and skin conductance. Contextual modulation of fear was characterized by bottom-up and top-down processing during Embodied and Conceptual fear, respectively. Multi-modal clustering showed modality-specific organization overall, with a weak but significant global EEG-autonomic association (Mantel test), and one validated cross-modal link between HRV (LF/HF) and EDA (SCR Conclusion: Fear manifested through both shared neurophysiological signatures and context-dependent cognitive-embodied variations. Combining immersive technology with multi-modal biophysical sensing presents an exploratory, ecologically-valid framework for emotion research that can inform future closed-loop, adaptive paradigms.

Indexed as

autonomicBVP/HRVEDAEEGemotionfearneuralpsychophysiology

Identifiers

PMID42824324
PMCPMC13627354

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.