ArticleFrontiers in endocrinology2026
Association of monocyte to high-density lipoprotein cholesterol ratio with non-calcified plaques in subclinical coronary atherosclerosis: a cross-sectional study in hypertensive patients.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hypertension is a major driver of atherosclerotic cardiovascular disease (ASCVD), many hypertensive patients harbor occult subclinical coronary atherosclerosis (SCA). The monocyte to high-density lipoprotein cholesterol ratio (MHR), a novel biomarker integrating inflammation and lipid metabolism, has emerged as a potential risk indicator. However, its value in identifying coronary artery characteristics in asymptomatic hypertensive populations remains unclear. We aimed to investigate the association between MHR and subclinical coronary atherosclerosis characteristics in asymptomatic hypertensive patients. Methods: We conducted a cross-sectional study enrolling 283 hypertensive patients who underwent coronary computed tomography angiography (CCTA) at Shenzhen Traditional Chinese Medicine Hospital between January 2019 and September 2024. Patients were categorized into quartiles (Q1-Q4) based on MHR levels. CCTA was used to evaluate coronary artery calcium score (CACS) and plaque characteristics (non-calcified, calcified, mixed). Multivariable logistic regression, restricted cubic spline (RCS), and receiver operating characteristic (ROC) curve analyses were performed. Results: There was a significant difference in the prevalence of non-calcified plaques across MHR quartiles ( Conclusion: Elevated MHR is independently and non-linearly associated with the presence of non-calcified plaques in hypertensive patients. Given that non-calcified plaques represent an active, lipid-driven inflammatory state, MHR may serve as a simple and cost-effective adjunctive biomarker to help identify individuals with a higher burden of such plaques in asymptomatic hypertensive patients. However, its role in clinical risk stratification requires validation in prospective studies.
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