SynthesisFrontiers in immunology2026
Immunometabolic crosstalk in knee osteoarthritis: a bibliometric and translational analysis (2000-2025).
Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Knee osteoarthritis (KOA) has traditionally been regarded as a localized degenerative joint disorder; however, accumulating evidence increasingly supports a critical role for immunometabolic dysfunction, chronic low-grade inflammation, and systemic metabolic alterations in disease initiation and progression. Although research in this multidisciplinary field is growing rapidly, the global intellectual structure, emerging mechanistic themes, and the evolution of the translation of KOA research remain inadequately documented. Methods: This study used a multi-database bibliometric and scientometric analysis with a hypothesis-generating translational synthesis, rather than a systematic review of intervention effects. We analyzed publications indexed in Web of Science, Scopus, and PubMed from 2000 to 2025. We used CiteSpace, VOSviewer, and Bibliometrix to analyze global research trends, collaboration networks, intellectual structure, and emerging themes in immunometabolic and inflammatory mechanisms in KOA. Results: A total of 783 publications were included. Annual research output increased substantially after 2015, reflecting growing recognition of systemic contributors to KOA. The United States and China were the largest contributors to the growth of international partnerships. Co-citation, keyword, and thematic analyses showed increasing research attention to metabolic syndrome, oxidative stress, innate immune activation, multimorbidity, and inflammatory signaling alongside traditional cartilage-focused research. Biomarker discovery, lifestyle intervention, phenotype stratification, and precision-intervention-focused therapies were emerging research hotspots, indicating the growing translational importance of metabolic and immune-mediated mechanisms in the pathogenesis of KOA. Conclusion: This analysis indicates increasing research attention to systemic immunometabolic factors alongside established joint-centered models of KOA. The identified research trajectories offer crucial translational insights and help inform the design of integrated approaches for risk stratification, prevention, and personalized management strategies involving targeting metabolic dysfunction, inflammatory signaling, and immune-mediated pathways in osteoarthritis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.