SynthesisFrontiers in cellular neuroscience2026
Research hotspots and emerging trends of macrophages in peripheral nerve injury: a bibliometric and visualization analysis.
Synthesis in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Peripheral nerve injury (PNI) remains a significant clinical challenge due to its poor neurological recovery. Macrophages serve as key regulators in pathological degeneration, inflammatory resolution, and regenerative repair after PNI. This study aims to explore the global status, research hotspots, and developmental trends of macrophage-related studies in PNI through bibliometric analysis. It further aimed to identify emerging research frontiers and existing knowledge gaps, thereby providing insights into optimized PNI repair strategies. Methods: Literature related to PNI and macrophages published from January 1, 2006, to March 31, 2026, was retrieved from the Web of Science Core Collection and Scopus databases. After literature screening, deduplication, and data standardization, VOSviewer, CiteSpace, and Bibliometrix were used to perform bibliometric analysis and visualization of countries, institutions, authors, journals, keywords, and citations. Results: A total of 694 publications were included. The annual publication output showed a continuous upward trend, with a marked increase after 2017 and a peak of 76 publications in 2025. A total of 50 countries contributed to this field. China had the highest number of publications, whereas the United States had the highest total number of citations. Nantong University was the most productive institution, and Kiguchi, Norikazu and Kishioka, Shiroh were the most productive authors. Conclusion: This study revealed the hotspots and trends of macrophage research in PNI over the past two decades. Research foci have expanded from basic pathological mechanisms to neuroimmune regulation and regenerative strategies. Combined omics and bioinformatics will help elucidate macrophage regulatory networks and advance precise interventions for PNI.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.