Evidence map›Paper›PMID 42824086›Full record

ArticleFrontiers in microbiology2026

Vancomycin-variable enterococci as a silent reservoir of resistance: characterization of the first reported vancomycin-variable

Abdessalam Cherkaoui, Patrice François, Gesuele Renzi, Nadia Gaïa, Eve-Julie Bonetti, Diego O Andrey, Jacques Schrenzel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abdessalam Cherkaoui *Bacteriology Laboratory, Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, Geneva, Switzerland.
Patrice François *Genomic Research Laboratory, Department of Molecular Microbiology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Gesuele RenziBacteriology Laboratory, Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, Geneva, Switzerland.
Nadia GaïaGenomic Research Laboratory, Department of Molecular Microbiology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Eve-Julie BonettiGenomic Research Laboratory, Department of Molecular Microbiology, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Diego O AndreyBacteriology Laboratory, Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, Geneva, Switzerland.
Jacques SchrenzelBacteriology Laboratory, Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study reports what is, to our knowledge, the first vancomycin-variable Methods: A vancomycin-susceptible, Results: The VVEfm isolate exhibited vancomycin and teicoplanin minimum inhibitory concentrations (MICs) of 1.5 mg/L despite harboring the Conclusion: This study reports the first identification of VVEfm at Geneva University Hospitals and highlights the limitations of routine phenotypic screening methods for detecting VVE isolates. The rapid emergence of high-level glycopeptide resistance under selective pressure suggests that these isolates may act as silent reservoirs of antimicrobial resistance. Integration of molecular diagnostics with phenotypic testing and genomic surveillance is essential to improve detection, infection control, and antimicrobial stewardship strategies.

Indexed as

antimicrobial susceptibility testingvanA clustervancomycin-resistant Enterococcus faeciumvancomycin-variable Enterococcus faeciumwhole-genome sequencing

Identifiers

PMID42824086
PMCPMC13627305

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.