SynthesisFrontiers in medicine2026
Evaluating the efficacy of intensified insulin therapy in hypertriglyceridemic acute pancreatitis management: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hypertriglyceridemia has long been regarded as a major cause of pancreatitis, and its incidence has been increasing annually. However, the role of intensified insulin therapy in treating hypertriglyceridemic acute pancreatitis (HTG-AP) remains debatable. Methods: A prospectively registered meta-analysis (CRD420261344642) was conducted to examine eligible randomized controlled trials (RCTs) or retrospective observational studies (ROSs) through searches across PubMed, Cochrane Library, and Embase databases, as well as the Web of Science, with a search period up to 1st March 2026. Eligible meta-analyses were selected based on predefined criteria. Data analysis was conducted using RevMan (version 5.4) and R (version 4.4.3). Results: A total of 12 studies including 1,505 patients were identified that compared the effectiveness of intensive insulin therapy with other treatment modalities in patients with HTG-AP. The results revealed a statistically non-significant difference in triglyceride reduction between intensive insulin therapy and other treatments (intensive insulin therapy versus other therapy: 24hTG, MD: 1.25, 95%CI: -0.53 to 3.03, Conclusions: Current evidence does not demonstrate the superiority of either intensive insulin therapy or blood purification, but intensive insulin therapy may shorten the length of hospital stay to a certain extent. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261344642, PROSPERO CRD420261344642.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.