ArticleFrontiers in neurology2026
Factors associated with orthostatic hypotension presence and severity in multiple system atrophy: a cross-sectional study.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The factors governing the presence and severity of orthostatic hypotension (OH) in multiple system atrophy (MSA) may differ. We investigated factors independently associated with OH and severe OH in MSA, and assessed the consistency of these associations across subtypes. Methods: We examined the clinical data of 242 MSA patients who had blood pressure evaluations to assess OH. We analyzed the clinical data of MSA patients with and without OH, as well as those with mild and severe OH, focusing on clinical characteristics and brain MRI features to identify factors associated with OH presence and severe OH. Results: OH was present in 136 patients (56.2%). MSA-C subtype (OR = 2.42, 95% CI = 1.33-4.43, Conclusion: Factors associated with OH presence differed from those associated with severe OH in MSA. MSA-C subtype, diagnostic certainty, and UMSARS-I score were associated with OH presence, whereas male sex and NMSS burden were associated with severe OH.
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