Evidence map›Paper›PMID 42823953›Full record

ArticleFrontiers in public health2026

Long-term exposure to low concentrations of ambient benzene with incident thyroid dysfunction and the mediating role of accelerated biological aging.

Liliang Yu, Changlai Lyu, Meiqi Liu, Bin Wang, Daikun Zheng, Yunhao Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Liliang Yu *Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Environmental Hygiene and Occupational Medicine, School of Public Health, Healthy Hubei Development and Social Progress Research Center of the Key Research Base of Humanities and Social Sciences in Hubei Province, Wuhan University of Science and Technology, Wuhan, Hubei, China.
Changlai Lyu *Department of Mathematics/Department of Computer Science and Engineering (CSE), The Hong Kong University of Science and Technology, Hong Kong, China.
Meiqi Liu *Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Environmental Hygiene and Occupational Medicine, School of Public Health, Healthy Hubei Development and Social Progress Research Center of the Key Research Base of Humanities and Social Sciences in Hubei Province, Wuhan University of Science and Technology, Wuhan, Hubei, China.
Bin WangSchool of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Daikun ZhengDepartment of Preventive Medicine, School of Public Health and Management, Chongqing Three Gorges Medical College, Chongqing, China.
Yunhao LiuHubei Province Key Laboratory of Occupational Hazard Identification and Control, Department of Environmental Hygiene and Occupational Medicine, School of Public Health, Healthy Hubei Development and Social Progress Research Center of the Key Research Base of Humanities and Social Sciences in Hubei Province, Wuhan University of Science and Technology, Wuhan, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The associations between ambient benzene exposure and thyroid dysfunction (hypothyroidism and hyperthyroidism), as well as the role of biological aging, remain largely unknown. Methods: We included a total of 385,130 participants from the UK Biobank, and Cox regressions were used to assess the association between benzene exposure and incident thyroid dysfunction. We employed restricted cubic splines to fit potential nonlinear exposure-response relationships. Furthermore, interactions and mediation analyses were conducted to examine the mediating role of biological aging. Results: Benzene exposure was dose-responsively associated with an increased risk of thyroid dysfunction, each 1 μg/m Conclusion: Long-term exposure to low concentrations benzene may increase the risk of incident thyroid dysfunction. Accelerated biological aging demonstrated a significant additive interaction with benzene exposure on the risk of hypothyroidism and partially mediated the positive association between benzene exposure and the risk of hyperthyroidism.

Indexed as

AgingAir PollutantsBenzeneEnvironmental ExposureHyperthyroidismHypothyroidismThyroid DiseasesAgedFemaleHumansIncidenceMaleMiddle AgedUnited KingdomAir PollutantsBenzeneaccelerated biological agingair pollutantbenzenehyperthyroidismhypothyroidismthyroid dysfunction

Identifiers

PMID42823953
PMCPMC13626889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.