Evidence map›Paper›PMID 42823949›Full record

ArticleFrontiers in cellular and infection microbiology2026

Performance comparison and clinical validation of two rapid direct identification and antimicrobial susceptibility testing approaches for pathogens isolated from positive blood cultures in children.

Fen Pan, Fangyuan Yu, Tiandong Zhang, Qin Cai, Jie Jiang, Hong Zhang, Pengcheng Chen, Wenhao Weng

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Fen Pan *Department of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Fangyuan Yu *Department of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Tiandong ZhangDepartment of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Qin CaiDepartment of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jie JiangDepartment of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Hong ZhangDepartment of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Pengcheng ChenDepartment of Clinical Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wenhao WengDepartment of Clinical Laboratory, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Rapid species identification and antimicrobial susceptibility testing (AST) for bloodstream infections (BSIs) are critical for timely and targeted therapy. This study evaluated the clinical performance of two rapid methods (HBL rapid method and rapid method with short-term culture) against the routine standard blood culture (BC) method. Methods: A total of 162 monobacterial BC samples were enrolled. These samples were processed either using the HBL system (subcultured within 2 hours) or incubated on agar plates for short-term culture (6-8 hours). Subsequent species identification and AST were also performed. Essential agreement (EA), categorical agreement (CA), and error rates were calculated as compared to the conventional method. Results: Among 162 isolates, Gram-negative bacteria comprised 66.7% (108/162) of the isolates, predominantly Conclusions: The two rapid methods exhibit exceptional accuracy and reliability for species identification and AST directly from positive blood cultures, which can significantly shorten the TAT for BSI diagnosis, offering clinicians to optimize timely and appropriate clinical treatment.

Indexed as

Anti-Bacterial AgentsBacteremiaBacteriaBacteriological TechniquesBlood CultureChildChild, PreschoolFemaleGram-Negative BacteriaHumansInfantMicrobial Sensitivity TestsTime FactorsAnti-Bacterial Agentsbloodstream infectionsclinical performancepositive blood culturerapid antimicrobial susceptibilityrapid identification

Identifiers

PMID42823949
PMCPMC13626878

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