ArticleNeurogastroenterology and motility2026
Diagnostic Value of the Anal Endoluminal Functional Luminal Imaging Probe for the Diagnosis of Anismus: An Exploratory Study.
Article in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04155307 (Is the Evaluation of Anal Distensibility by Endoflip® Technique Useful for the Diagnosis of Anismus?), which is not on this map. Cited by 1 paper.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Is the Evaluation of Anal Distensibility by Endoflip® Technique Useful for the Diagnosis of Anismus?
Who cites it
1 citing paper in PubMed.
- Diagnostic Value of the Anal Endoluminal Functional Luminal Imaging Probe for the Diagnosis of Anismus: An Exploratory Study.Neurogastroenterology and motility · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe aim of this exploratory study was to evaluate the performance of the anal EndoFLIP in diagnosing anismus in patients with functional constipation and suspected to have a dyssynergic defecation based on a composite reference standard (anorectal manometry, surface electromyography, and defecography).
methodsPatients underwent anorectal manometry, surface electromyography, and defecography. At least two of the three tests needed to be positive to diagnose anismus. Anal EndoFLIP was performed during push maneuvers at 40 and 50 mL of distension, and pressure-cross-sectional-area (CSA) loops were built for each push maneuver to identify parameters that could best predict a diagnosis of anismus (ROC curve analysis). Two-variable CSA-pressure classifiers were evaluated using nested repeated five-fold cross-validation.
resultsDiagnosis of anismus using the composite reference standard was made in 29/57 patients (50.8%). An analysis of CSA-pressure loops indicated that, at 40 mL of distension, maximal absolute ΔCSA and maximal relative ΔCSA were lower compared to patients without anismus (p < 0.001). Among quantitative CSA indices, an exploratory threshold under 12.8 mm
conclusionThe results suggest that anal EndoFLIP may help distinguish patients with anismus from those without. Further external validation studies are needed to establish clinically applicable thresholds.
trial registrationClinical. TRIALS: gov: NCT04155307.
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