Evidence map›Paper›PMID 42823769›Full record

ReviewAntimicrobial resistance and infection control2026

Carbapenem-resistant Enterobacterales in Europe: strengthening AMR resilience through coordinated system-level action - lessons from Ukraine.

Luise Martin, Arina Zanuzdana, Martin Weber, Nataliia Aliieva, Liliia Mykhajliv, Maryana Svirchuk, Mariia Boiko, Artem Horbachevskyi, Hailie Uren, Brar Christian Piening and 4 more

Abstract readLetterReview
In one paragraph

Review in Antimicrobial resistance and infection control, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Luise Martin *Medical Directorate, Charité - University Medical Center Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. luise.martin@charite.de.ORCID 0000-0001-6936-1574
Arina Zanuzdana *Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
Martin WeberMedical Directorate, Charité - University Medical Center Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Nataliia AliievaFirst Lviv Territorial Medical Union, Lviv, Ukraine.
Liliia MykhajlivFirst Lviv Territorial Medical Union, Lviv, Ukraine.
Maryana SvirchukFirst Lviv Territorial Medical Union, Lviv, Ukraine.
Mariia BoikoRegional Clinical Hospital of Ivano-Frankivsk, Ivano-Frankivsk, Ukraine.
Artem HorbachevskyiPublic Health Center of the Ministry of Health of Ukraine, Kyiv, Ukraine.
Hailie UrenPublic Health Center of the Ministry of Health of Ukraine, Kyiv, Ukraine.
Brar Christian PieningInstitute of Hygiene and Environmental Medicine, National Reference Centre for Surveillance of Nosocomial Infections, Charité - University Medical Center Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Beate KampmannCharité Centre for Global Health, Charité - University Medical Center Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Tim EckmannsDepartment of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany.
Joachim Seybold *Medical Directorate, Charité - University Medical Center Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Miriam Songa Stegemann *Medical Directorate, Charité - University Medical Center Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbapenem-resistant Enterobacterales (CRE) have emerged as one of the most serious antimicrobial resistance (AMR) threats in Europe. Rising incidence, substantial mortality, and marked heterogeneity across the EU/EEA pose a growing challenge. In Ukraine, an already substantial AMR burden and pre-existing limitations in diagnostic and infection prevention capacity, infectious diseases and antimicrobial stewardship (AMS) expertise, workforce resources, and access to effective antimicrobials have been further exacerbated by the war, including through damage to healthcare infrastructure and disruption of supply chains. These conditions facilitate the emergence and spread of CRE. As patient movement across Europe continues, CRE in Ukraine has become a shared European health security challenge. Although numerous national and international initiatives support AMR control in Ukraine, their impact is limited by fragmented implementation, insufficient coordination, and limited visibility across stakeholders. Drawing on hospital partnerships, multidisciplinary expert discussions, and emerging national coordination efforts in Ukraine, we argue that sustainable CRE control requires an integrated, system-level framework combining strengthened microbiological diagnostics and surveillance, infection prevention and control, infectious diseases and AMS expertise, and equitable access to effective antimicrobials. These components should be embedded within a coordinated national framework that aligns international support with national priorities. We describe the recently established, Ukrainian-led Public Health Center of the Ministry of Health of Ukraine (PHC) AMR Coordination Working Group as an emerging example, combining regular technical engagement, structured stakeholder collaboration, and plans to map international AMR-related activities in Ukraine. This approach may inform future European efforts to organise international AMR support in other high-burden and crisis-affected settings.

Indexed as

Anti-Bacterial AgentsCarbapenem-Resistant EnterobacteriaceaeEnterobacteriaceae InfectionsAntimicrobial StewardshipEuropeHumansPublic Health InfrastructureUkraineAnti-Bacterial AgentsAntimicrobial resistanceAntimicrobial stewardshipCarbapenem-resistant EnterobacteralesEuropeHealth securityImplementationInfection prevention and controlUkraine

Identifiers

PMID42823769
PMCPMC13632363

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.