Evidence map›Paper›PMID 42823765›Full record

ArticleThe journal of headache and pain2026

Resting-state local brain functional synchronization after a single trigger-zone stimulation: with versus without evoked pain in classical trigeminal neuralgia patients.

Xiuhong Ge, Luoyu Wang, Juncheng Yan, Lei Pan, Haiqi Ye, Yuting Zhang, Lidan Fang, Huan Chen, Wenhua Yu, Quan Du and 1 more

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In one paragraph

Article in The journal of headache and pain, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Xiuhong Ge *Department of Radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, No.261, Huansha Road, Shangcheng District, Hangzhou City, Zhejiang Province, China.ORCID http://orcid.org/0000-0002-4217-4864
Luoyu Wang *Department of Radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, No.261, Huansha Road, Shangcheng District, Hangzhou City, Zhejiang Province, China.
Juncheng YanDepartment of Rehabilitation, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China.
Lei PanDepartment of Radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, No.261, Huansha Road, Shangcheng District, Hangzhou City, Zhejiang Province, China.ORCID http://orcid.org/0000-0003-4282-8239
Haiqi YeDepartment of Radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, No.261, Huansha Road, Shangcheng District, Hangzhou City, Zhejiang Province, China.
Yuting ZhangDepartment of Radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, No.261, Huansha Road, Shangcheng District, Hangzhou City, Zhejiang Province, China.
Lidan FangDepartment of Radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, No.261, Huansha Road, Shangcheng District, Hangzhou City, Zhejiang Province, China.
Huan ChenDepartment of Radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, No.261, Huansha Road, Shangcheng District, Hangzhou City, Zhejiang Province, China.
Wenhua YuDepartment of Neurosurgery, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China. ywh699@126.com.ORCID http://orcid.org/0000-0003-0566-6066
Quan DuDepartment of Neurosurgery, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou, China. duquan76@zuaa.zju.edu.cn.
Zhongxiang DingDepartment of Radiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, No.261, Huansha Road, Shangcheng District, Hangzhou City, Zhejiang Province, China. hangzhoudzx73@126.com.ORCID http://orcid.org/0000-0001-7691-5571

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClassical trigeminal neuralgia (CTN) is characterized by transient, stimulus-evoked pain attacks, but post-stimulation changes in local brain synchronization remain unclear. We characterized static and dynamic local functional synchronization at baseline and during resting-state scans initiated after a single trigger-zone stimulation.

methodsBaseline analyses included 44 healthy controls (HC), 80 CTN patients with stimulation-evoked pain (CTN

resultsAt baseline, group differences were observed in Frontal_Med_Orb_R, Insula_L/R, and Hippocampus_R/L. Insula_R dReHo and Frontal_Med_Orb_R ReHo differed between CTN

conclusionsCTN subgroups defined by the observed pain-evocation outcome differed in baseline and temporal measures of resting-state local synchronization. Baseline Insula_R dReHo was the subgroup-associated measure but should not be interpreted as causal or predictive. Exploratory group × time interactions and imaging-clinical correlations provide preliminary evidence that requires independent replication. These findings reflect post-stimulation resting-state alterations rather than acute activation.

Indexed as

BrainTrigeminal NeuralgiaAdultAgedBrain MappingElectric StimulationFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedRestBrain functionClassical trigeminal neuralgiaDynamic regional homogeneityPain statesRegional homogeneityResting-state fMRITrigger-zone stimulation

Identifiers

PMID42823765
PMCPMC13628961

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.