ReviewEarly intervention in psychiatry2026
Transdiagnostic Biomarkers of Psychopathology: A Conceptual Review.
Review in Early intervention in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
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Authors and funding
5 authors.
Funding
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Abstract
introductionPsychiatric biomarker research has traditionally been organized around diagnostic categories, but clinical heterogeneity, comorbidity and shared biological mechanisms across psychiatric conditions have increased interest in transdiagnostic approaches. These approaches may be especially relevant for early recognition, stratification and intervention planning. Despite this growing interest, the concept of the transdiagnostic biomarker remains unclear. This conceptual review aimed to clarify how transdiagnostic biomarkers of psychopathology are represented in psychiatric research.
methodsSystematically identified empirical literature and concept explication were used to examine biomarker modalities, indexed psychopathology-related constructs, transdiagnostic framing and conceptual boundary issues across studies.
resultsTransdiagnostic biomarker research was found to encompass several approaches, including diagnosis-spanning comparisons, symptom-based models, subgroup-based approaches, cross-domain extensions beyond traditional psychiatric categories and research aligned with alternative frameworks such as the Research Domain Criteria or the Hierarchical Taxonomy of Psychopathology. A conceptual framework is proposed comprising three linked elements: the measurable indicator, the psychopathology-related construct and the transdiagnostic scope of that construct. Within this framework, a transdiagnostic biomarker is defined as a measurable biological or biobehavioural indicator of a psychopathology-related construct that spans multiple diagnostic categories or extends beyond them.
conclusionGreater conceptual clarity of transdiagnostic biomarkers may strengthen psychiatric biomarker discovery by improving construct alignment and supporting their use in biomarker-informed stratification, early intervention, treatment selection, prognosis and precision psychiatry.
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