A Coumarin-Derived Fluorescent Probe For The Rapid Detection Of Nitroaromatic Explosives TNP and PYX.

Junli Shi, Shengling Li, Congying Li, Xinyuan Xue, Yue Zhao, Mingya Wang, Linxiu Zhao, Fanfan Shen, Duanlin Cao

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Article in Journal of fluorescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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9 authors.

Junli ShiSchool of Environment and Safety Engineering, North University of China, Taiyuan, 030051, China.

Shengling LiDepartment of Chemistry and Chemical Engineering, Taiyuan Institute of Technology, Taiyuan, 030008, China.

Congying LiShanxi Beihua Guanlv Chemical Industry Co, Ltd, Yongji, 044500, China.

Xinyuan XueSchool of Chemistry and Chemical Engineering, North University of China, Taiyuan, 030051, China.

Yue ZhaoSchool of Chemistry and Chemical Engineering, North University of China, Taiyuan, 030051, China.

Mingya WangSchool of Environment and Safety Engineering, North University of China, Taiyuan, 030051, China.

Linxiu ZhaoSchool of Chemistry and Chemical Engineering, North University of China, Taiyuan, 030051, China.

Fanfan ShenSchool of Chemistry and Chemical Engineering, North University of China, Taiyuan, 030051, China.

Duanlin CaoSchool of Chemistry and Chemical Engineering, North University of China, Taiyuan, 030051, China. cdl@nuc.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitroaromatic explosives are the most commonly used military explosives. In this study, the known compound (E)-7-(diethylamino)-3-(3-(4-(dimethylamino)phenyl)acryloyl)-2H-chromen-2-one (hereinafter referred to as CKY) was employed as a fluorescent probe to systematically investigate its fluorescence response toward the nitroaromatic explosives 2,4,6-trinitrophenol (TNP) and 2,6-bis(picrylamino)-3,5-dinitropyridine (PYX). CKY showed rapid response (within 10 s) and pronounced fluorescence quenching toward TNP and PYX, with detection limits (LOD) of 3.37 µM and 1.86 µM, respectively. Combined with spectroscopic analysis and theoretical calculations, the fluorescence quenching mechanism of the probe toward the target analytes was discussed. In terms of practical applications, CKY-loaded test strips integrated with smartphone-based color recognition software were developed to establish a semiquantitative detection method for TNP and PYX. Furthermore, the response of the probe to exogenous TNP and PYX was evaluated in living HeLa cells, and satisfactory results were obtained. This work not only expands the application of the known compound CKY in the field of nitroaromatic explosive detection but also provides a candidate material for the rapid detection of TNP and PYX.

Indexed as

Cell imagingFluorescent probeInner filter effectNitroaromatic explosives

Identifiers

PMID42823596

DOI10.1016/j.saa.2023.123753

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