Evidence map›Paper›PMID 42823562›Full record

ArticleEuropean radiology2026

Angio-CT does not increase patient radiation exposure compared to conventional cone-beam CT for intra-arterial liver procedures.

Charlotte Schneider, Han Keijzers, Erik Jan Rijkhorst, Kenneth Hergaarden, Tarik Baetens, Regina Beets-Tan, Belinda de Wit-van der Veen, Elisabeth Klompenhouwer

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Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Charlotte SchneiderDepartment of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Han KeijzersDepartment of Medical Physics and Technology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Erik Jan RijkhorstDepartment of Medical Physics and Technology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Kenneth HergaardenDepartment of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Tarik BaetensDepartment of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Regina Beets-TanGROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands.
Belinda de Wit-van der Veen *Department of Nuclear Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Elisabeth Klompenhouwer *Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. l.klompenhouwer@nki.nl.ORCID http://orcid.org/0000-0002-4497-3838

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo evaluate patient radiation dose during intra-arterial liver procedures using Computed Tomography angiography (angio-CT) compared with C-arm Cone-Beam CT (CBCT). MATERIAL AND

methodsThis retrospective study included bland embolization and radioembolization mapping procedures performed between November 2021 and December 2024 using dual-phase angio-CT or single-phase CBCT on a hybrid angiography suite. Effective dose was calculated by converting dose-area and dose-length product using conversion factors. Fluoroscopy-only (2D), CBCT/angio-CT (3D) effective dose and total effective dose were compared using the Mann-Whitney U-test. Bootstrap resampling and permutation testing with Monte Carlo error propagation were applied to assess the robustness of 3D and total effective dose comparisons.

resultsNinety-two procedures were included: 48 in the CBCT group and 44 in the angio-CT group. The 2D effective dose was comparable. The 3D effective dose was 4.1-fold lower in the angio-CT group (median 9.85 [IQR: 5.37-22.6 mSv] vs 39.9 mSv [IQR: 21.2-69.6 mSv], p < 0.001), resulting in 1.6-fold reduction in total effective dose for procedures performed by angio-CT (median 34.6 [IQR: 23.7-54.3 mSv] vs 55.9 mSv [IQR: 37.6-103 mSv], p < 0.001). After dose conversion uncertainty correction, corrected p-values were < 0.001 for 3D effective dose and 0.053 for the total dose.

conclusionHybrid angiography suites incorporating angio-CT significantly reduced 3D effective dose compared to single-phase CBCT imaging. However, the total effective dose did not remain significant after uncertainty correction. Therefore, the use of angiography suites incorporating dual-phase angio-CT does not appear to change patient radiation exposure during intra-arterial liver procedures. KEY POINTS: Question What is the effect of integrating angio-CT into hybrid angiography suites on patient radiation exposure? Findings Dual-phase angio-CT integration into intra-arterial liver therapy workflows does not increase overall procedural radiation exposure and is associated with a decreased 3D effective dose. Clinical relevance Angio-CT offers several clinical advantages, and existing literature demonstrates improved image quality compared with CBCT. This study shows that dual-phase angio-CT does not increase patient radiation exposure compared to single-phase CBCT, supporting its use when available.

Indexed as

Angio-CTBland embolizationCone-beam computed tomographyRadiation exposureRadioembolization

Identifiers

PMID42823562

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.