ReviewNature chemical biology2026
Advances in amidases and urethanases as depolymerization biocatalysts.
Review in Nature chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Stable chemical bonds as well as noncovalent interactions define the properties of industrial chemicals and materials, including polyesters such as polyethylene terephthalate (PET), polyamides (nylons) and polyurethanes. The resistance of plastics to hydrolysis contributes to the global issues of waste accumulation and environmental pollution. Recently identified metagenomic enzymes act on highly stable ester, amide and carbamate bonds in small molecules as well as pretreated polymeric materials. However, depolymerization activities, particularly for nylons and polyurethanes, remain too low to facilitate the efficient treatment of plastic waste. This Perspective highlights the natural diversity of different hydrolase superfamilies suitable for deconstructing synthetic polymers and examines their catalytic features. We also discuss strategies for discovering biocatalysts and tailoring their properties by protein engineering-both assisted by bioinformatics and (ultra)high-throughput screening tools. The combination of these approaches and thorough process analyses will be required to advance hydrolase-based depolymerization of plastics beyond the current recycling schemes for PET.
Identifiers
42823503What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.