ArticleCommunications biology2026
Biotope-dependent resistance to reactive oxygen species, antibiotic tolerance, and virulence of Staphylococcus aureus.
Vincent Léguillier, Karine Gloux, Majd Khalife, Rochelle D'Mello, Zoran Minic, Milica Sentic, Marta Catto, Marisa Manzano, Christine Péchoux, Sandrine Truchet and 5 more
Abstract read
In one paragraphArticle in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Vincent LéguillierUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy en Josas, France.ORCID 0000-0002-5585-2986 Karine GlouxUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy en Josas, France.
Majd KhalifeUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy en Josas, France.ORCID 0000-0002-5846-9755 Rochelle D'MelloUniversity of Ottawa, Department of Chemistry and Biomolecular Sciences, John L. Holmes Mass Spectrometry Facility, Ottawa, ON, Canada.
Zoran MinicUniversity of Ottawa, Department of Chemistry and Biomolecular Sciences, John L. Holmes Mass Spectrometry Facility, Ottawa, ON, Canada.
Milica SenticUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy en Josas, France.ORCID 0000-0002-9740-0769 Marta CattoUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy en Josas, France.
Marisa ManzanoUniversità di Udine, Dipartimento di Scienze AgroAlimentari, Ambientali e Animali, Udine, Italy.ORCID 0000-0002-3543-6141 Christine PéchouxUniversité Paris-Saclay, INRAE, GABI, Jouy en Josas, France.
Sandrine TruchetUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy en Josas, France.ORCID 0000-0002-7737-9202 Philippe GauduUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy en Josas, France.ORCID 0000-0002-9061-7316 Christina Nielsen-LerouxUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy en Josas, France.ORCID 0000-0002-9335-446X Brahim HeddiLaboratoire de Biologie et de Pharmacologie Appliquée, CNRS UMR8113, École Normale Supérieure Paris-Saclay, Gif sur Yvette, France.ORCID 0000-0002-5535-6237 Alexandra GrussUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy en Josas, France.ORCID 0000-0001-7426-5229 Jasmina VidicUniversité Paris-Saclay, INRAE, AgroParisTech, Micalis Institute, Jouy en Josas, France. jasmina.vidic@inrae.fr.ORCID 0000-0002-8549-8199 Funding
Agence Nationale de la Recherche (French National Research Agency) ANR-16-CE15-0013Agence Nationale de la Recherche (French National Research Agency) ANR-21-CE42-008European Commission (EC) 101135402European Commission (EC) 872662Fondation pour la Recherche Médicale (Foundation for Medical Research in France) DBF20161136769Joint Programming Initiative on Antimicrobial Resistance (Joint Programming Initiative for Antimicrobial Resistance) ANR-22-AAMR-0007Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja (Ministry of Education, Science and Technological Development of the Republic of Serbia) 451-03-136/2025-03/200026
6 · The paper itselfAbstract
The human and livestock pathogen Staphylococcus aureus poses a major clinical challenge due to antibiotic treatment failure. Its resilience is mainly attributed to antibiotic resistance and tolerance mechanisms related to persistence. Here we investigate how two infection-relevant conditions, milk and serum, shape S. aureus pathogenic properties and capacity to withstand environmental stresses. Milk- versus serum-grown bacteria show gross differences in envelope physical properties, membrane fatty acid composition and rigidity, and pigment production, and display distinct proteomic profiles. Compared to growth in serum, S. aureus grown in milk exhibits extreme resistance to ROS damage, marked antimicrobial tolerance, and accelerated killing in a larval infection model. High level S. aureus pigmentation in whole milk is stimulated by milk lipids, and is responsible for high ROS resistance. The remarkable robustness of S. aureus in a milk biotope may signal the need to adjust antibiotic regimens when treating mastitis infections in humans and livestock.
Indexed as
Anti-Bacterial AgentsDrug Resistance, BacterialReactive Oxygen SpeciesStaphylococcal InfectionsStaphylococcus aureusAnimalsFemaleHumansMilkVirulenceAnti-Bacterial AgentsReactive Oxygen Species
Identifiers
PMID42823449
PMCPMC13631261
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