Evidence map›Paper›PMID 42823433›Full record

ArticlePediatric research2026

Prenatal exposure to hypertensive disorders and adolescent brain white matter development.

Vida Rebello, Yinging Xia, Nicole M Talge, Hedyeh Ahmadi, Andrew O Odegaard, Veronica M Vieira, Marybel R Gonzalez, Eric Kan, Bernadette Boden-Albala, Kristina A Uban

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Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vida RebelloDepartment of Health, Society and Behavior, University of California, Irvine, Joe C Wen School of Population & Public Health, Irvine, CA, USA. vrebello@uci.edu.
Yinging XiaDepartment of Health, Society and Behavior, University of California, Irvine, Joe C Wen School of Population & Public Health, Irvine, CA, USA.
Nicole M TalgeDepartment of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA.
Hedyeh AhmadiUniversity Statistical Consulting, LLC, Irvine, CA, USA.
Andrew O OdegaardDepartment of Epidemiology and Biostatistics, University of California, Irvine, Joe C Wen School of Population & Public Health, Irvine, CA, USA.
Veronica M VieiraDepartment of Environmental and Occupational Health, University of California, Irvine, Joe C Wen School of Population & Public Health, Irvine, CA, USA.
Marybel R GonzalezDepartment of Psychiatry and Behavioral Health, The Ohio State University, Ohio, OH, USA.
Eric KanChildren's Hospital Los Angeles, and the Department of Pediatrics, University of Southern California, Los Angeles, CA, USA.
Bernadette Boden-AlbalaDepartment of Health, Society and Behavior, University of California, Irvine, Joe C Wen School of Population & Public Health, Irvine, CA, USA.
Kristina A UbanDepartment of Health, Society and Behavior, University of California, Irvine, Joe C Wen School of Population & Public Health, Irvine, CA, USA. kuban@uci.edu.

Funding

NIAAA NIH HHS K01AAA026889UCI Conte Center MH096889
6 · The paper itself

Abstract

backgroundHypertensive disorders of pregnancy (HDP) are associated with altered in utero neurodevelopment, yet long-term impact on adolescent white matter architecture remains unclear, particularly by HDP subtype and sex. While preeclampsia/eclampsia (P/E) is clinically more severe, pregnancy-related hypertension (PR-HTN) may involve longer in-utero exposure to hemodynamic stress. This study examined how distinct HDP exposures influence longitudinal white matter measures in adolescents.

methodsUsing a longitudinal cohort with two MRI timepoints (baseline ages 9-11 years; 2-year follow-up ages 11-13.8 years), we modeled fiber volume (FV) and fractional anisotropy (FA) using linear mixed-effects models. Analyses were sex-stratified and adjusted for prenatal exposures, maternal age, race/ethnicity, and income. False discovery rate (FDR) correction was applied.

resultsIn female adolescents, PR-HTN was significantly associated with lower FV across bilateral association, projection, and limbic pathways, alongside reduced FV and FA in the corpus callosum and forceps major/minor (q < 0.05). Conversely, P/E exposure showed no FDR-significant associations. No significant associations were observed in males for either HDP subtype.

conclusionChronic in-utero exposure to PR-HTN, rather than acute P/E, is associated with widespread reductions in white matter structural integrity in females. These findings support subtype-specific and developmentally sensitive associations between HDP exposure and offspring brain development. IMPACT: This study demonstrates that pregnancy-related hypertension, a traditionally "milder" disorder, has more pronounced long-term impacts on adolescent white matter scaffolding than preeclampsia/eclampsia. The results highlight a female-specific vulnerability to chronic prenatal hypertensive stress, manifesting as reduced volumetric and microstructural integrity in critical commissural and association white matter tracts. These findings shift the clinical focus toward the neurodevelopmental risks of chronic gestational hypertension, suggesting that maternal cardiovascular health throughout the entire pregnancy is a vital determinant of offspring brain development.

Identifiers

PMID42823433

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