Evidence map›Paper›PMID 42822418›Full record

ArticleMolecular cell2026

Conserved and divergent mitochondrial assemblies in kinetoplastid parasites.

Md Solayman, Yi-Ting Liao, Sarah E Calvo, Andres F Vacas, Malvina Papanastasiou, Keith D Rivera, D R Mani, Brian W Boyle, Felicia G Deng, MitoCarta Tree of Life Consortium and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Md SolaymanDepartment of Molecular and Cell Biology, Boston University Medical Campus, Boston, MA 02118, USA.
Yi-Ting LiaoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
Sarah E CalvoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA.
Andres F VacasDepartment of Molecular and Cell Biology, Boston University Medical Campus, Boston, MA 02118, USA.
Malvina PapanastasiouBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Keith D RiveraBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
D R ManiBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Brian W BoyleBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Felicia G DengDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA.
MitoCarta Tree of Life Consortium
Namrata D UdeshiBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Vamsi K MoothaDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Massachusetts General Hospital, Boston, MA 02114, USA.
Inna AphasizhevaDepartment of Molecular and Cell Biology, Boston University Medical Campus, Boston, MA 02118, USA.
Luke H ChaoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: chao@molbio.mgh.harvard.edu.
Ruslan AphasizhevDepartment of Molecular and Cell Biology, Boston University Medical Campus, Boston, MA 02118, USA. Electronic address: ruslana@bu.edu.

Funding

Guide RNA Binding ComplexR01AI101057 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Ruslan Afasizhev · 2012 to 2026
$6.0M
REPEAT-CONTAINING RNA BINDING PROTEINS OF TRYPANOSOMESR01AI113157 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AFASIZHEVA, INNA · 2015 to 2024
$4.6M
Probing structural and biophysical mechanisms of mitochondrial membrane ultrastructureR35GM142553 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI Luke H. Chao · 2021 to 2026
$2.6M
Mitochondrial RNA Uridylation in TrypanosomesR01AI177658 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Ruslan Afasizhev · 2024 to 2026
$2.1M
TRANSCRIPTIONAL CONTROL OF MITOCHONDRIAL GENE EXPRESSION IN TRYPANOSOMESR01AI152408 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AFASIZHEV, RUSLAN · 2020 to 2024
$2.1M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI101057NIAID NIH HHS R01 AI113157NIAID NIH HHS R01 AI152408NIAID NIH HHS R01 AI177658NIGMS NIH HHS R35 GM142553
6 · The paper itself

Abstract

The mitochondrial proteomes of Leishmania tarentolae and Trypanosoma brucei contain ∼1,700 proteins, most of which lack homologs in higher eukaryotes. Here, we integrate complexome profiling and cryo-electron microscopy to define conserved and lineage-specific macromolecular assemblies that support mitochondrial functions in these kinetoplastid protozoa. Comparative analyses reveal species- and life-stage-dependent differences in the abundance and composition of respiratory, metabolic, RNA processing, and other complexes, refining and expanding current annotations. Structures of L. tarentolae respiratory complex III

Indexed as

LeishmaniaMitochondriaMitochondrial ProteinsProtozoan ProteinsTrypanosoma brucei bruceiAnimalsCryoelectron MicroscopyModels, MolecularProteomeMitochondrial ProteinsProteomeProtozoan Proteinscomplexome profilingcryo-EMkinetoplastidsLeishmaniamass spectrometrymitochondriarespiratory complexesRNA editingTrypanosoma

Identifiers

PMID42822418
PMCPMC13631411

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.