Evidence map›Paper›PMID 42822007›Full record

ArticleOncoimmunology2026

A novel oncolytic peptide synergizing with immunotherapy.

Guido Kroemer, Xiaolian Deng, Baldur Sveinbjørnsson, Oliver Kepp

Abstract read
In one paragraph

Article in Oncoimmunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guido KroemerInserm, Centre de Recherche des Cordeliers, Equipe labellisée Par la Ligue Contre le Cancer, Université Paris Cité, Sorbonne Université, Institut Universitaire de France, Paris, France.ORCID 0000-0002-9334-4405
Xiaolian DengInserm, Centre de Recherche des Cordeliers, Equipe labellisée Par la Ligue Contre le Cancer, Université Paris Cité, Sorbonne Université, Institut Universitaire de France, Paris, France.
Baldur SveinbjørnssonLytix Biopharma, Oslo, Norway.ORCID 0009-0000-3894-3301
Oliver KeppInserm, Centre de Recherche des Cordeliers, Equipe labellisée Par la Ligue Contre le Cancer, Université Paris Cité, Sorbonne Université, Institut Universitaire de France, Paris, France.ORCID 0000-0002-6081-9558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In a recent paper published in Nature, Yuan et al. described an acid-responsive membranolytic peptide that temporally separates lysosomes from later plasma membrane rupture, thereby converting oncolysis into immunogenic cell death. This elegant design permits systemic administration, elicits antigen-specific immunity, and sensitizes tumors to programmed death ligand 1 blockade with remarkably limited toxicity.

Indexed as

ImmunotherapyNeoplasmsPeptidesAnimalsB7-H1 AntigenHumansB7-H1 AntigenPeptidesautophagyHMGB1ImmunotherapyPD-L1

Identifiers

PMID42822007
PMCPMC13641581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.