Evidence map›Paper›PMID 42821294›Full record

Trial reportJournal of speech, language, and hearing research : JSLHR2026

Dose Considerations and Generalization Following Script Training for Poststroke Aphasia: A Randomized Factorial Clinical Trial.

Leora R Cherney, Laura E Kinsey, Erin E Blaze, Elizabeth L Gray, Mary J Kwasny, Sarel Van Vuuren

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of speech, language, and hearing research : JSLHR, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leora R CherneyCenter for Aphasia Research & Treatment, Shirley Ryan AbilityLab, Chicago, IL.ORCID 0000-0003-3754-4450
Laura E KinseyCenter for Aphasia Research & Treatment, Shirley Ryan AbilityLab, Chicago, IL.ORCID 0009-0002-9037-1827
Erin E BlazeCenter for Aphasia Research & Treatment, Shirley Ryan AbilityLab, Chicago, IL.
Elizabeth L GrayDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0001-9298-6927
Mary J KwasnyDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.ORCID 0000-0003-3287-1903
Sarel Van VuurenInstitute of Cognitive Science, University of Colorado Boulder.ORCID 0000-0002-0355-9067

Funding

Modulating stimulus intensity to improve clinical outcomes in aphasia treatmentR01DC016979 · NIDCD · REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB · PI CHERNEY, LEORA R, VAN VUUREN, SAREL · 2019 to 2023
$3.3M
Research Symposium in Communication Sciences and DisordersR13DC003383 · NIDCD · AMERICAN SPEECH-LANGUAGE-HEARING ASSN · PI MARGARET A. ROGERS · 1997 to 2026
$727k
NIDCD NIH HHS R01 DC016979NIDCD NIH HHS R13 DC003383
6 · The paper itself

Abstract

purposeUsing script training as an intervention, this study modulated the dose parameters of stimulus repetition (i.e., long vs. short scripts) and session frequency (i.e., distributed vs. massed practice) and assessed their impact on maintenance and generalization in people with chronic poststroke aphasia.

methodThe study was a single-site, factorial, single-blind randomized controlled trial. Participants were randomized in a 2 × 2 factorial design into one of four study arms, stratified by pretreatment aphasia severity: (a) distributed/short script, (b) distributed/long script, (c) massed/short script, and (d) massed/long script. Participants completed 10, 1-hr sessions of computer-based script training. Participants were assigned to one of four levels of script complexity with levels determined by aphasia severity. The primary generalization outcome measured performance on the trained script in a simulated conversation with a familiar speech-language pathologist posttreatment. Secondary outcomes included evaluating (a) maintenance of the primary outcome at 3 and 6 weeks posttreatment and (b) generalization of the trained script content to an unstructured conversation with an unfamiliar, naive partner at baseline, posttreatment, and 6 weeks posttreatment.

resultsEighty-five participants with aphasia enrolled in the study. There was no significant difference between groups from baseline to posttreatment and follow-up for stimulus repetition, but there was a significant difference for session frequency with massed performing better than distributed. Factor interactions over time indicated that long scripts showed greater improvements with distributed versus massed session frequency, whereas short scripts were better maintained than long scripts at 6-week follow-up. Within groups, there was significant improvement from baseline to posttreatment, which was generally maintained at 6 weeks posttreatment.

conclusionsResults provide further evidence supporting the efficacy of script training. Dose parameters such as session frequency and stimulus repetition may impact the maintenance and generalization of treatment and should be considered when delivering this and other aphasia treatments. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.33990859.

Indexed as

AphasiaGeneralization, PsychologicalLanguage TherapySpeech TherapyStrokeStroke RehabilitationAgedFemaleHumansMaleMiddle AgedSingle-Blind MethodTreatment Outcome

Identifiers

PMID42821294
PMCPMC13678535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.