Evidence map›Paper›PMID 42821219›Full record

ArticleBulletin of experimental biology and medicine2026

Morphological and Molecular-Biological Characteristics of Wound Healing in Animals with High and Low Hypoxia Tolerance.

D Sh Dzhalilova, I S Tsvetkov, M V Kirillova, E A Melnikova, V A Mkhitarov, M A Diatroptova, O V Makarova

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Article in Bulletin of experimental biology and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

D Sh DzhalilovaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia. juliajal93@mail.ru.
I S TsvetkovAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
M V KirillovaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
E A MelnikovaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
V A MkhitarovAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
M A DiatroptovaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
O V MakarovaAvtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The morphological and molecular genetic characteristics of wound healing were investigated in male Wistar rats with high and low hypoxia tolerance (HT and HS rats, respectively). A full-thickness skin wound (diameter 16 mm) was inflicted in the interscapular region. On day 11 after wound infliction (proliferation phase), histological examination and morphometric analysis of the wound tissue were performed. The expression of the Hif1a, Epas1, Vegf, Nfkb, Il1b, Il6, Il10, Tnfa, and Tgfb genes in intact skin and in the wound granulation tissue was assessed by PCR, and the serum levels of HIF-1α, IL-1β, IL-6, and IL-10 were detected by ELISA. On day 11 of wound healing, reparative processes were more pronounced in HT animals, manifesting as a significantly smaller wound area compared to HS rats. The ratio of collagen fiber types on day 11 of wound healing in HT and HS rats did not differ significantly. Compared to HT rats, HS animals demonstrated higher expression of the Il6 and Tgfb genes in the granulation tissue, and higher serum levels of IL-6 protein. These data should be considered when conducting studies using animals with different hypoxia tolerance.

Indexed as

cytokineshypoxia toleranceratsskin wound

Identifiers

PMID42821219

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