Evidence map›Paper›PMID 42821186›Full record

ArticleOphthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)2026

Age-Related Changes in Differential Corneal Thickness and Their Correlation with With-the-Rule and Against-the-Rule Corneal Astigmatism.

Dandan Liao, Xiangjie Zeng, Shuangfeng Liang, Chunyang Zhou

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Article in Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Dandan LiaoEye School of Chengdu University of TCM, Chengdu, China.
Xiangjie ZengEye School of Chengdu University of TCM, Chengdu, China.
Shuangfeng LiangEye School of Chengdu University of TCM, Chengdu, China.
Chunyang ZhouEye School of Chengdu University of TCM, Chengdu, China. zhouchunyang@cdutcm.edu.cn.

Funding

Sichuan Provincial Science and Technology Plan 2023YFS0506
6 · The paper itself

Abstract

objectiveTo analyse age-related changes in differential corneal thickness (DCT) and curvature (DCC) between the two principal meridians and between the vertical and horizontal meridians, and to examine their relationship with with-the-rule (WTR) and against-the-rule (ATR) astigmatism.

methodsThis retrospective study included 400 patients (100 per age group: 6-20, 21-40, 41-60 and ≥61 years). The left eye was analysed for each participant. Corneal thickness (CT) and curvature (CC) were measured within the central 3 mm zone along the two principal, vertical and horizontal meridians. The mean differential thickness (DCT1) and curvature (DCC1) between the two principal meridians, as well as the mean differential thickness (DCT2) and curvature (DCC2) between the vertical and horizontal meridians were calculated and compared across age groups. To account for axis orientation, power vector transformation was applied to DCC1, decomposing it into DCC1

resultsDCT1 decreased with age but showed no significant change in the WTR subgroup (p = 0.14), indicating the apparent decline was driven by age-related shifts in axis composition. DCT2 remained stable across age groups (p = 0.19). DCC1

conclusionsAfter controlling for axis orientation in the WTR subgroup, DCT1 and DCT2 did not vary with age. The significant age-related decreases in DCC1

Indexed as

Against-the-rule astigmatismAgeAnterior corneal curvatureCorneal thicknessWith-the-rule astigmatism

Identifiers

PMID42821186

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.