Evidence map›Paper›PMID 42821128›Full record

ArticleMikrochimica acta2026

Serum-compatible aptamer-regulated RCA-CRISPR/Cas12a assay for fluorescence and lateral flow detection of myeloperoxidase.

Yingying Cao, Mengchen Duan, Lizhen Wei, Yisheng Chen, Fei Liu, Jiawen Bai, Yi Huang, Shenghang Zhang

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yingying Cao *Fuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, 350002, P. R. China.
Mengchen Duan *Zhongxiang People's Hospital, Zhongxiang, 431900, P. R. China.
Lizhen WeiFujian Key Laboratory of Aptamers Technology, Fuzong Clinical Medical College of Fujian Medical University (900th Hospital), Fuzhou, 350025, P. R. China.
Yisheng ChenFuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, 350002, P. R. China.
Fei LiuFujian Key Laboratory of Aptamers Technology, Fuzong Clinical Medical College of Fujian Medical University (900th Hospital), Fuzhou, 350025, P. R. China.
Jiawen BaiFujian Key Laboratory of Aptamers Technology, Fuzong Clinical Medical College of Fujian Medical University (900th Hospital), Fuzhou, 350025, P. R. China.
Yi HuangFuzhou University Affiliated Provincial Hospital, Fuzhou University, Fuzhou, 350002, P. R. China. Huangyi@fjsl.com.cn.
Shenghang ZhangFujian Key Laboratory of Aptamers Technology, Fuzong Clinical Medical College of Fujian Medical University (900th Hospital), Fuzhou, 350025, P. R. China. fzzyyzsh@126.com.

Funding

Fujian Medical University Qihang funds 2023QH1706the National Filing Science and Technology Project 2024L3020
6 · The paper itself

Abstract

Myeloperoxidase (MPO), a neutrophil-derived heme peroxidase involved in oxidative inflammatory responses, has been investigated as a biomarker for cardiovascular, hematological, and other inflammation-associated diseases. In this study, an aptamer-regulated rolling circle amplification (RCA)-CRISPR/Cas12a fluorescence assay was established for MPO detection in serum samples. Two aptamers, Apt-02 and Apt-14, were obtained with dissociation constants (K

Indexed as

Aptamers, NucleotideBiosensing TechniquesCRISPR-Cas SystemsPeroxidaseBacterial ProteinsCRISPR-Associated ProteinsEndodeoxyribonucleasesFluorescenceHumansLimit of DetectionNucleic Acid Amplification TechniquesSpectrometry, FluorescenceAptamers, NucleotideBacterial ProteinsCas12a proteinCRISPR-Associated ProteinsEndodeoxyribonucleasesMPO protein, humanPeroxidaseAptamer-based biosensingCRISPR/Cas12aLateral-flow stripMPO detectionRolling circle amplification (RCA)Serum sample analysis

Identifiers

PMID42821128

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.