Evidence map›Paper›PMID 42821126›Full record

ArticleJournal of neurology2026

Multimodal PET-MRI profiling predicts dementia with Lewy bodies in isolated REM sleep behaviour disorder.

Andreas Myhre Baun, Alex Iranzo, Miriam Højholt Terkelsen, Rainer Hinz, Morten Gersel Stokholm, Mónica Serradell, Kristina Bacher Svendsen, Alicia Garrido, Dolores Vilas, Arne Møller and 6 more

Abstract read
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In one paragraph

Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andreas Myhre BaunDepartment of Nuclear Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, Aarhus N, J220, 8200, Aarhus, Denmark. andreasbaun@clin.au.dk.ORCID http://orcid.org/0009-0007-8099-1367
Alex IranzoNeurology Service, Department of Neurology, Hospital Clínic de Barcelona, 08036, Barcelona, Spain. airanzo@clinic.cat.
Miriam Højholt TerkelsenDepartment of Nuclear Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, Aarhus N, J220, 8200, Aarhus, Denmark.
Rainer HinzWolfson Molecular Imaging Centre, University of Manchester, Manchester, UK.
Morten Gersel StokholmDepartment of Nuclear Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, Aarhus N, J220, 8200, Aarhus, Denmark.
Mónica SerradellNeurology Service, Department of Neurology, Hospital Clínic de Barcelona, 08036, Barcelona, Spain.
Kristina Bacher SvendsenDepartment of Neurology, Aarhus University Hospital, Aarhus, Denmark.
Alicia GarridoCentro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Catalonia, Spain.
Dolores VilasParkinson Disease and Movement Disorders Unit, Neurology Service, Hospital Clínic de Barcelona, Barcelona, Catalonia, Spain.
Arne MøllerCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Carles GaigNeurology Service, Department of Neurology, Hospital Clínic de Barcelona, 08036, Barcelona, Spain.
Eduardo TolosaCentro de Investigación Biomédica en Red Sobre Enfermedades Neurodegenerativas (CIBERNED), Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Catalonia, Spain.
David J BrooksDepartment of Nuclear Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, Aarhus N, J220, 8200, Aarhus, Denmark.
Per BorghammerDepartment of Nuclear Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, Aarhus N, J220, 8200, Aarhus, Denmark.
Simon Fristed EskildsenCenter of Functionally Integrative Neuroscience, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Nicola PaveseDepartment of Nuclear Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 165, Aarhus N, J220, 8200, Aarhus, Denmark.

Funding

Danmarks Frie Forskningsfond 4004-00480BDanmarks Frie Forskningsfond 8020-00260BInstituto de Salud Carlos III CB06/05/0018Parkinsonforeningen R4-A104-B60
6 · The paper itself

Abstract

Despite isolated REM sleep behaviour disorder (iRBD) reliably identifying individuals at high risk of developing Parkinson's disease (PD) or dementia with Lewy bodies (DLB), with more than 90% converting, the neurobiological markers of the conversion phenotype are not fully understood. Most previous studies have found univariate imaging biomarkers of phenoconversion, and most of these lack specificity for PD and DLB. Using a well-characterised iRBD cohort (N=21), receiving multiple PET and MRI scans, we aimed to assess if the inter-modality relationship can specifically predict conversion to PD or DLB. The patients received [

Indexed as

Lewy Body DiseaseMagnetic Resonance ImagingPositron-Emission TomographyREM Sleep Behavior DisorderAgedAged, 80 and overDisease ProgressionDopaminergic ImagingFemaleHumansMaleMultimodal ImagingParkinson DiseaseDementia with Lewy bodiesMRIParkinson’s diseasePETREM sleep behaviour disorder

Identifiers

PMID42821126

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.