Evidence map›Paper›PMID 42821042›Full record

ArticleMolecular biology reports2026

GSDME upregulation predicts poor prognosis in gastric cancer.

Yeqiong Xu, Yaoyao Zhuang, Huanhuan Chen, Tianwei Guo, Zhidong Shao, Jie Chen, Yimai Deng, Yanping Zhu, Chuandan Wan, Yulan Gu

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Yeqiong Xu *Center Laboratory of Changshu Medical Examination Institute, Changshu, Jiangsu Province, China.
Yaoyao Zhuang *Center Laboratory of Changshu Medical Examination Institute, Changshu, Jiangsu Province, China.
Huanhuan Chen *Center Laboratory of Changshu Medical Examination Institute, Changshu, Jiangsu Province, China.
Tianwei GuoDepartment of Pathology, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu, Jiangsu, China.
Zhidong ShaoDepartment of Clinical Laboratory, Meili People's Hospital, Changshu, Jiangsu Province, China.
Jie ChenCenter Laboratory of Changshu Medical Examination Institute, Changshu, Jiangsu Province, China.
Yimai DengCenter Laboratory of Changshu Medical Examination Institute, Changshu, Jiangsu Province, China.
Yanping ZhuCenter Laboratory of Changshu Medical Examination Institute, Changshu, Jiangsu Province, China.
Chuandan WanCenter Laboratory of Changshu Medical Examination Institute, Changshu, Jiangsu Province, China. cd_wan@163.com.
Yulan GuDepartment of Oncology, Affiliated Changshu Hospital of Nantong University, Changshu, Jiangsu Province, China. guyulan@263.net.

Funding

Changshu Science and Technology Project CS202241Changshu Science and Technology Project CS202434Changshu Science and Technology Project CY202328Changshu Science and Technology Project CY202330hangshu Commission of Health Project CSWS202106
6 · The paper itself

Abstract

backgroundPyroptosis is an inflammatory form of programmed cell death characterized by rapid plasma membrane rupture and the release of intracellular mediators, which distinguishes it from apoptosis and necrosis. Pyroptosis plays important roles in infection, autoimmunity, and cancer, highlighting its significance in immune homeostasis. Gasdermin E (GSDME), a key executor of pyroptosis, has been increasingly implicated in cancer. This study examined the expression and prognostic significance of GSDME in stomach adenocarcinoma (STAD). METHODS AND

resultsGSDME was significantly upregulated in STAD tissue and associated with advanced stage and poor prognosis according to data from The Cancer Genome Atlas (TCGA) and the Xiantao Academic Online tool. Gene set enrichment analysis (GSEA) revealed that high GSDME expression was associated with genes enriched in immunosuppressive-related pathways in the TCGA-STAD cohort stratified by GSDME expression. Immune analysis revealed that GSDME expression was positively correlated with immune cell infiltration and the expression of immune checkpoint molecules, lymphocyte markers, immunomodulators, and major histocompatibility complex (MHC) molecules, as determined using R software and the Tumor-Immune System Interactions and Drug Bank (TISIDB). Western blotting and immunohistochemistry confirmed the elevated expression of GSDME in gastric cancer (GC) tissues. Functional analysis revealed that GSDME knockdown inhibited the proliferation and migration of AGS and MKN-45 GC cells while promoting cell death.

conclusionsThese findings suggest that GSDME may serve as a prognostic biomarker in GC and as a potential immune regulator.

Indexed as

AdenocarcinomaPore Forming Cytotoxic ProteinsReceptors, EstrogenStomach NeoplasmsBiomarkers, TumorCell Line, TumorCell ProliferationFemaleGasderminsGene Expression Regulation, NeoplasticHumansMaleMiddle AgedPrognosisPyroptosisUp-RegulationBiomarkers, TumorGasderminsGSDME protein, humanPore Forming Cytotoxic ProteinsReceptors, EstrogenGastric cancerGSDMEPrognosisPyroptosisTumor microenvironment

Identifiers

PMID42821042

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.